SynthesisBlood transfusion = Trasfusione del sangue2019
Red blood cell alloimmunisation in transfusion-dependent thalassaemia: a systematic review.
Synthesis in Blood transfusion = Trasfusione del sangue, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- [Guideline for transfusion management in Chinese children with transfusion-dependent thalassemia (2025)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Guideline
- Red cell specifications for blood group matching in patients with haemoglobinopathies: An updated systematic review and clinical practice guideline from the International Collaboration for Transfusion Medicine Guidelines.British journal of haematology · 2025Pooled it
- Would a National Antibody Register contribute to improving patient outcomes?Blood transfusion = Trasfusione del sangue · 2022Pooled it
- Irregular antibodies in paediatric haematological disorders: Prevalence and characteristics from a Vietnamese tertiary centre.Vox sanguinis · 2026Article
- Article
- Clinical integration of red cell genotyping in children with β-thalassemia major: a prospective observational study.Blood global hematology · 2026Article
- Survey of Red Cell Transfusion Therapy and Immunohematology Services for Patients with Hemoglobinopathies in TürkiyeTurkish journal of haematology : official journal of Turkish Society of Haematology · 2025Article
- Association between HLA-DRB1*04, HLA-DQB1*03, and HLA-DQB1*06 with alloimmunization in transfusion-dependent patients with thalassemia: the first case-control study in Iran.Annals of hematology · 2025Article
- Transfusion in hemoglobinopathies and red blood cell alloimmunization: data from Sicily, Sardinia and Malta.Blood transfusion = Trasfusione del sangue · 2024Article
- Characterization of pediatric transfusion-dependent thalassemia patients in a large academic center.Journal of clinical laboratory analysis · 2023Article
- Red blood cell alloimmunization and other transfusion-related complications in patients with transfusion-dependent thalassemia: A multi-center study in Thailand.Transfusion · 2022Article
- The transfusion management of beta thalassemia in the United States.Transfusion · 2021Review
- Comprehensive management of refractory autoimmune hemolytic anemia in pediatric beta-thalassemia major patient: A case report.Annals of medicine and surgery (2012) · 2021Article
- Response to Measles, Mumps and Rubella (MMR) Vaccine in Transfusion-Dependent Patients.Vaccines · 2021Article
- Luspatercept: A Gigantic Step in the Treatment of Transfusion-Dependent β-Thalassemia Patients-a Quick Review.Advances in therapy · 2021Review
- Rh alloimmunization in chronically transfused patients with thalassemia receiving RhD, C, E, and K matched transfusions.Blood advances · 2021Article
- Management of Iron Overload in Beta-Thalassemia Patients: Clinical Practice Update Based on Case Series.International journal of molecular sciences · 2020Review
- Analysis of red cell alloimmunization in multi transfused patients at a Tertiary care teaching hospital.Journal of family medicine and primary care · 2020Article
- Amustaline-glutathione pathogen-reduced red blood cell concentrates for transfusion-dependent thalassaemia.British journal of haematology · 2019Article
- The Red Blood Cell-Improving Transfusions for Chronically Transfused Recipients (RBC-IMPACT) study: protocol description of an international multi-site observational clinical study.Blood transfusion = Trasfusione del sangueReview
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic red blood cell transfusion is the first-line treatment for severe forms of thalassaemia. This therapy is, however, hampered by a number of adverse effects, including red blood cell alloimmunisation. The aim of this systematic review was to collect the current literature data on erythrocyte alloimmunisation. MATERIALS AND
methodsWe performed a systematic search of the literature which identified 41 cohort studies involving 9,256 patients.
resultsThe prevalence of erythrocyte alloimmunisation was 11.4% (95% CI: 9.3-13.9%) with a higher rate of alloimmunisation against antigens of the Rh (52.4%) and Kell (25.6%) systems. Overall, alloantibodies against antigens belonging to the Rh and Kell systems accounted for 78% of the cases. A higher prevalence of red blood cell alloimmunisation was found in patients with thalassaemia intermedia compared to that among patients with thalassaemia major (15.5 vs 12.8%). DISCUSSION: Matching transfusion-dependent thalassaemia patients and red blood cell units for Rh and Kell antigens should be able to reduce the risk of red blood cell alloimmunisation by about 80%.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.