Evidence map›Paper›PMID 30653418›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2019

Local arginase inhibition does not modulate cutaneous vasodilation or sweating in young and older men during exercise.

Robert D Meade, Naoto Fujii, Gregory W McGarr, Lacy M Alexander, Pierre Boulay, Ronald J Sigal, Glen P Kenny

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Robert D MeadeHuman and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa , Ottawa, ON , Canada.
Naoto FujiiHuman and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa , Ottawa, ON , Canada.
Gregory W McGarrHuman and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa , Ottawa, ON , Canada.
Lacy M AlexanderDepartment of Kinesiology, Noll Laboratory, Pennsylvania State University , University Park, Pennsylvania.
Pierre BoulayFaculty of Physical Activity Sciences, University of Sherbrooke , Sherbrooke, QC , Canada.
Ronald J SigalHuman and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa , Ottawa, ON , Canada.
Glen P KennyHuman and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa , Ottawa, ON , Canada.

Funding

CIHR 286363
6 · The paper itself

Abstract

Age-related impairments in cutaneous vascular conductance (CVC) and sweat rate (SR) during exercise may result from increased arginase activity, which can attenuate endogenous nitric oxide (NO) production. We therefore evaluated whether arginase inhibition modulates these heat-loss responses in young (

Indexed as

AdultArginaseArginineBody TemperatureExerciseForearmHumansMaleMiddle AgedNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseSkinSkin Physiological PhenomenaSweatingVasodilationArginaseArgininearginine methyl esterNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide Synthaseagingheat stressnitric oxideskin blood flowsweating

Identifiers

PMID30653418
PMCPMC6485684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.