Evidence map›Paper›PMID 30653391›Full record

ArticleAutophagy2019

Mechanistic insight into the regulation of SQSTM1/p62.

Yi Zhang, Su Ran Mun, Juan F Linares, Christina G Towers, Andrew Thorburn, Maria T Diaz-Meco, Yong Tae Kwon, Tatiana G Kutateladze

Open access · bronzeAbstract readComment
In one paragraph

Article in Autophagy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Guideline
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  9. mAutophagy · 2022
    Article
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  12. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yi Zhanga Department of Pharmacology , University of Colorado School of Medicine , Aurora , CO , USA.ORCID 0000-0001-8170-9983
Su Ran Munb Protein Metabolism Medical Research Center and Department of Biomedical Sciences, College of Medicine , Seoul National University , Seoul , Republic of Korea.
Juan F Linaresc Cancer Metabolism and Signaling Networks Program , Sanford Burnham Prebys Medical Discovery Institute , La Jolla , CA , USA.
Christina G Towersa Department of Pharmacology , University of Colorado School of Medicine , Aurora , CO , USA.
Andrew Thorburna Department of Pharmacology , University of Colorado School of Medicine , Aurora , CO , USA.
Maria T Diaz-Mecoc Cancer Metabolism and Signaling Networks Program , Sanford Burnham Prebys Medical Discovery Institute , La Jolla , CA , USA.
Yong Tae Kwonb Protein Metabolism Medical Research Center and Department of Biomedical Sciences, College of Medicine , Seoul National University , Seoul , Republic of Korea.
Tatiana G Kutateladzea Department of Pharmacology , University of Colorado School of Medicine , Aurora , CO , USA.ORCID 0000-0001-7375-6990
University of Colorado Denver · USSanford Burnham Prebys Medical Discovery Institute · USSeoul National University · KR

Funding

Role of autophagy in tumor cell deathR01CA150925 · NCI · UNIVERSITY OF COLORADO DENVER · PI DEGREGORI, JAMES V · 2010 to 2024
$5.5M
Training Program in Cancer BiologyT32CA190216 · NCI · UNIVERSITY OF COLORADO DENVER · PI Craig T. Jordan · 2016 to 2026
$3.5M
Role of p62 in metabolic reprograming of the tumor stroma in prostate cancerR01CA218254 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DIAZ MECO CONDE, MARIA TERESA, METALLO, CHRISTIAN MICHAEL · 2017 to 2021
$2.6M
Therapeutic targeting of autophagy-dependent cancerR01CA190170 · NCI · UNIVERSITY OF COLORADO DENVER · PI GUSTAFSON, DANIEL L, THORBURN, ANDREW M · 2015 to 2019
$2.5M
The p62/MEKK3 complex in mTORC1 activationR01CA192642 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI DIAZ MECO CONDE, MARIA TERESA · 2015 to 2019
$2.2M
Molecular analysis of methylated p53R01GM101664 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2013 to 2016
$1.7M
Epigenetic regulation by PHF1R01GM106416 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2015 to 2018
$1.5M
Molecular mechanism of chromatin targeting by BRPF1R01GM100907 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2015 to 2018
$1.4M
Interdomain crosstalk in MORC3R01GM125195 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2017 to 2021
$1.3M
NCI NIH HHS R01 CA150925NCI NIH HHS R01 CA190170NCI NIH HHS R01 CA192642NCI NIH HHS R01 CA218254NCI NIH HHS T32 CA190216NIGMS NIH HHS R01 GM100907NIGMS NIH HHS R01 GM101664NIGMS NIH HHS R01 GM106416NIGMS NIH HHS R01 GM125195
6 · The paper itself

Abstract

SQSTM1/p62 facilitates responses to various cellular stresses and has been implicated in human diseases. This protein functions as a major cytoplasmic signaling hub and has multiple binding partners, including arginylated (Nt-R) proteins that are recognized by the ZZ domain of SQSTM1/p62 (SQSTM1/p62

Indexed as

AutophagyHumansSequestosome-1 ProteinSignal TransductionSequestosome-1 ProteinSQSTM1 protein, humanArginylated substratesautoregulationmacroautophagyp62ZZ domain

Identifiers

PMID30653391
PMCPMC6526835
OpenAlexW2909985432

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.