Evidence map›Paper›PMID 30653126›Full record

SynthesisMedicine2019

The efficacy of local liposomal bupivacaine infiltration on pain and recovery after Total Joint Arthroplasty: A systematic review and meta-analysis of randomized controlled trials.

Baocheng Zhao, Xinlong Ma, Jinli Zhang, Jianxiong Ma, Qing Cao

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04539730 (Does the Addition of Liposomal Bupivacaine to the Adductor Canal Block Impact Narcotic Use After Primary Total Knee Arthroplasty), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04539730 phase4withdrawnnot on this mapstarted 2021, after this paper: background citation

Does the Addition of Liposomal Bupivacaine to the Adductor Canal Block Impact Narcotic Use After Primary Total Knee Arthroplasty: a Prospective, Blind Randomized Control Trial

TypeinterventionalSponsorUniversity of MiamiRan2021 to 2022Enrolled0ConditionsArthroplasty Complications, Adductor Canal Block, Peripheral Nerve Block, Opioid UseArmsLiposomal bupivacaine, Drug: SoC Ropivacaine
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Reduction of Opioid Use With Enhanced Recovery Program for Total Knee Arthroplasty.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2021
    Article
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Baocheng ZhaoTrauma knee department 1, Tianjin Hospital, Tianjin.
Xinlong MaBiomechanics Labs of Orthopaedics Institute, Tianjin Hospital, Tianjin, People's Republic of China.
Jinli ZhangTrauma knee department 1, Tianjin Hospital, Tianjin.
Jianxiong MaBiomechanics Labs of Orthopaedics Institute, Tianjin Hospital, Tianjin, People's Republic of China.
Qing CaoTrauma knee department 1, Tianjin Hospital, Tianjin.
Tianjin Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTotal Joint Arthroplasty (TJA) is gradually emerging as the treatment of choice for end-stage osteoarthritis. In the past, Perioperative liposomal bupivacaine treatment is still a controversial subject in TJA. Therefore, we write this systematic review and meta-analysis to evaluate the efficacy of liposomal bupivacaine on pain and recovery after TJA. MATERIALS AND

methodsEmbase, Pubmed, and Cochrane Library were comprehensively searched. Randomized controlled trials (RCTs), cohort studies were included in our meta-analysis. Twelve studies that compared liposomal bupivacaine groups with placebo groups were included in our meta-analysis. The research was reported according to the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. RCTs were included in our meta-analysis.

resultsOur study demonstrated that liposomal bupivacaine group was as effective as the placebo group in term of VAS score at 24 h (P = .09), 48 h (P = .97); Postoperative nausea (P = .72); and LOS (0.27). There was significant difference in terms of total morphine consumption at 24 h (P < .0001), 48 h (P = .0008).

conclusionOur meta-analysis demonstrated that liposomal bupivacaine has similar pain control and functional recovery after TJA which compared with the control group. However, we still need large sample size, high-quality studies to explore the relationship between complications and dose response to give the final conclusion.

Indexed as

AgedAnalgesics, OpioidAnesthetics, LocalArthroplasty, Replacement, KneeBupivacaineFemaleHumansMaleMiddle AgedMorphineOsteoarthritisPain MeasurementPostoperative PainRandomized Controlled Trials as TopicRecovery of FunctionTreatment OutcomeAnalgesics, OpioidAnesthetics, LocalBupivacaineMorphine

Identifiers

PMID30653126
PMCPMC6370122
OpenAlexW2909794893

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.