Evidence map›Paper›PMID 30652987›Full record

ArticlePsychosomatic medicine2019

Coronary Artery Spasm as Related to Anxiety and Depression: A Nationwide Population-Based Study.

Ming-Yow Hung, Chun-Tai Mao, Ming-Jui Hung, Jiunn-Kae Wang, Hsin-Chien Lee, Chi-Tai Yeh, Patrick Hu, Tien-Hsing Chen, Nen-Chung Chang

Abstract read
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In one paragraph

Article in Psychosomatic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
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  4. Mental health status and cardiovascular outcomes across Life's Essential 8 categories.International journal of cardiology. Cardiovascular risk and prevention · 2025
    Article
  5. Review
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  7. Navigating the heart - insights into human coronary artery innervation.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024
    Article
  8. Review
  9. Review
  10. Coronary Artery Spasm-Related Heart Failure Syndrome: Literature Review.International journal of molecular sciences · 2023
    Review
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  12. Review
  13. Article
  14. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Ming-Yow HungFrom the Division of Cardiology (Hung), Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City; Department of Internal Medicine (Hung), School of Medicine, College of Medicine, Taipei Medical University, Taipei City; Division of Cardiology (Mao, Hung, Chen), Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Chang Gung University College of Medicine, Taoyuan; Department of Psychiatry (Wang, Lee), Shuang Ho Hospital, Taipei Medical University, New Taipei City; Department of Psychiatry (Wang, Lee), School of Medicine, College of Medicine, Taipei Medical University, Taipei City; Department of Medical Research and Education (Yeh), Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; University of California (Hu), Riverside; Department of Cardiology (Hu), Riverside Medical Clinic, California; and Division of Cardiology (Chang), Department of Internal Medicine, Taipei Medical University Hospital, Taiwan.
Chun-Tai Mao
Ming-Jui Hung
Jiunn-Kae Wang
Hsin-Chien Lee
Chi-Tai Yeh
Patrick Hu
Tien-Hsing Chen
Nen-Chung Chang
Tao Yuan General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAnxiety and depression are risk factors for obstructive coronary artery disease (CAD), but their effects on coronary artery spasm (CAS) remain unestablished.

methodsPatient records in this population-based study were retrospectively collected from the Taiwan National Health Insurance Research Database. Using propensity score matching, we used 1:1:1 ratio stratification into a control group of 10,325 individuals without CAS or CAD, a CAS group comprising 10,473 patients, and a CAD group comprising 10,473 patients during 2000-2012.

resultsThe prevalence of CAS and CAD was 0.067% and 8.7%, respectively, in the general population. The prevalence of anxiety and depression diagnoses was significantly higher in patients with new-onset CAS than in those with new-onset CAD and controls without CAS/CAD, even after propensity score matching. Compared with CAD, anxiety and depression diagnoses conferred a higher risk of developing CAS (odds ratio [OR] = 2.29, 95% confidence interval [CI], 2.14-2.45, p < .001, and OR = 1.34, 95% CI, 1.08-1.66, p = .007, respectively). The association was even stronger when comparing CAS with the control group without CAD or CAS (OR = 5.20, 95% CI, 4.72-5.74, p < .001, and OR = 1.98, 95% CI, 1.50-2.62, p < .001, respectively). The increased risk of new-onset CAS as related to previous anxiety and depression diagnoses was comparable between males and females.

conclusionsCompared with CAD or the general population, anxiety and depression diagnoses confer a higher risk of developing CAS. No sex differences are found for the association of anxiety and depression with CAS.

Indexed as

AdultAgedAged, 80 and overAnxiety DisordersCase-Control StudiesComorbidityCoronary Artery DiseaseDatabases, FactualDepressive DisorderFemaleHumansMaleMiddle AgedPropensity ScoreRetrospective StudiesRisk

Identifiers

PMID30652987
OpenAlexW2914236249

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.