ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2019
Subjective social status and inflammatory gene expression.
Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Glucocorticoid resistance and β2-adrenergic receptor signaling pathways promote peripheral pro-inflammatory conditions associated with chronic psychological stress: A systematic review across species.Neuroscience and biobehavioral reviews · 2021Pooled it
- Psychological stress and social support are associated with opposing single-cell pro-inflammatory gene regulatory mechanisms in adults.bioRxiv : the preprint server for biology · 2025Article
- A female-biased gene expression signature of dominance in cooperatively breeding meerkats.Molecular ecology · 2024Article
- Childhood maltreatment, subjective social status, and health disparities in bereavement.Psychoneuroendocrinology · 2022Article
- Stressor-Induced Reduction in Cognitive Behavior is Associated with Impaired Colonic Mucus Layer Integrity and is Dependent Upon the LPS-Binding Protein Receptor CD14.Journal of inflammation research · 2022Article
- Does inflammation link stress to poor COVID-19 outcome?Stress and health : journal of the International Society for the Investigation of Stress · 2021Review
- Socioeconomic status trajectories across the life course, daily discrimination, and inflammation among Black and white adults.Psychoneuroendocrinology · 2021Article
- Neurobiological Bases of Social Networks.Frontiers in psychology · 2021Review
- COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options.Cardiovascular research · 2020Article
- Subjective social status and health during high school and young adulthood.Developmental psychology · 2020Article
- PsychoBehavioroimmunology: Connecting the Behavioral Immune System to Its Physiological Foundations.Frontiers in psychology · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveThere exists a well-established link between low perceived social status and poorer health outcomes. However, the molecular mechanisms associated with this link remain unclear. This study begins to fill this gap by investigating the effects of low perceived subjective social status on health-related gene expression.
methodParticipants were 47 healthy heterosexual women (mean age 20.5 years) from a large American university. Participants gave 10 mL of peripheral blood and completed questionnaires assessing subjective social status (SSS), perceived childhood socioeconomic status (SES), health, and relevant demographics. Putatively associated genes were subject to TELiS promoter-based bioinformatic analysis to assess activity of proinflammatory, anti-inflammatory, and antiviral transcription factors.
resultsIn analyses controlling for perceived childhood socioeconomic status (SES) and other covariates, 84 transcripts showed >1.5-fold difference in average expression across the range of SSS. TELiS bioinformatics analyses implicated the proinflammatory transcription factors, NF-κB and AP-1, in driving expression of genes that were up-regulated in low-SSS individuals. Results also indicated increased activity of CREB family transcription factors but no differential activity of the anti-inflammatory glucocorticoid receptor of interferon response factors. Transcript origin analysis implicated monocytes and dendritic cells as cellular mediators.
conclusionIn this first study examining the molecular correlates of SSS, experiences of low social status are associated with transcriptional effects similar to those previously observed for objective adversity conditions such as low SES, social isolation, and chronic stress. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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