Evidence map›Paper›PMID 30652884›Full record

ArticleJournal of abnormal psychology2019

Association between negative cognitive bias and depression: A symptom-level approach.

Christopher G Beevers, Michael C Mullarkey, Justin Dainer-Best, Rochelle A Stewart, Jocelyn Labrada, John J B Allen, John E McGeary, Jason Shumake

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Journal of abnormal psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07139834 (Examining the Effects of Escitalopram and Memantine on Pattern Separation in Major Depressive Disorder), which is not on this map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07139834 phase1recruitingnot on this mapstarted 2026, after this paper: background citation

Examining the Effects of Escitalopram and Memantine on Pattern Separation in Major Depressive Disorder

TypeinterventionalSponsorJeffrey MillerRan2026 to 2027Enrolled30ConditionsMajor Depressive Disorder (MDD)ArmsSSRI (escitalopram or sertraline), Extended-Release Memantine, Placebo
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 130 citations in OpenAlex.

  1. Trial
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  3. Trial
  4. Article
  5. Article
  6. Negative Hits Hit Different.Affective science · 2026
    Article
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  8. Article
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  19. Tell me why: the missing w in episodic memory's what, where, and when.Cognitive, affective & behavioral neuroscience · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Christopher G BeeversDepartment of Psychology and Institute for Mental Health Research, The University of Texas at Austin.ORCID 0000-0002-4480-0902
Michael C MullarkeyDepartment of Psychology and Institute for Mental Health Research, The University of Texas at Austin.
Justin Dainer-BestDepartment of Psychology and Institute for Mental Health Research, The University of Texas at Austin.
Rochelle A StewartDepartment of Psychology and Institute for Mental Health Research, The University of Texas at Austin.ORCID 0000-0002-9680-6556
Jocelyn LabradaDepartment of Psychology and Institute for Mental Health Research, The University of Texas at Austin.
John J B AllenDepartment of Psychology, University of Arizona.
John E McGearyProvidence Veterans Affairs.
Jason ShumakeDepartment of Psychology and Institute for Mental Health Research, The University of Texas at Austin.ORCID 0000-0003-4655-436X
Texas Research Institute · USProvidence VA Medical Center · USUniversity of Arizona · US

Funding

Development of Attention Bias Modification for DepressionR33MH109600 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI BEEVERS, CHRISTOPHER G, SCHNYER, DAVID M · 2017 to 2019
$2.0M
Contribution of Genome-Wide Variation to Cognitive Vulnerability to DepressionR56MH108650 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI ALLEN, JOHN J., BEEVERS, CHRISTOPHER G · 2016 to 2016
$767k
Machine Learning and Personalized Prognosis for Depression TreatmentR21MH110758 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI BEEVERS, CHRISTOPHER G · 2016 to 2017
$430k
NIH HHSNIMH NIH HHS R21 MH110758NIMH NIH HHS R33 MH109600NIMH NIH HHS R56 MH108650
6 · The paper itself

Abstract

Cognitive models of depression posit that negatively biased self-referent processing and attention have important roles in the disorder. However, depression is a heterogeneous collection of symptoms and all symptoms are unlikely to be associated with these negative cognitive biases. The current study involved 218 community adults whose depression ranged from no symptoms to clinical levels of depression. Random forest machine learning was used to identify the most important depression symptom predictors of each negative cognitive bias. Depression symptoms were measured with the Beck Depression Inventory-II. Model performance was evaluated using predictive R-squared (Rpred2), the expected variance explained in data not used to train the algorithm, estimated by 10 repetitions of 10-fold cross-validation. Using the self-referent encoding task (SRET), depression symptoms explained 34% to 45% of the variance in negative self-referent processing. The symptoms of sadness, self-dislike, pessimism, feelings of punishment, and indecision were most important. Notably, many depression symptoms made virtually no contribution to this prediction. In contrast, for attention bias for sad stimuli, measured with the dot-probe task using behavioral reaction time (RT) and eye gaze metrics, no reliable symptom predictors were identified. Findings indicate that a symptom-level approach may provide new insights into which symptoms, if any, are associated with negative cognitive biases in depression. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Indexed as

AdolescentAdultAttentionAttentional BiasCognition DisordersDepressionDepressive DisorderEmotionsFemaleFixation, OcularHumansMalePersonality InventoryReaction TimeResearch DesignYoung Adult

Identifiers

PMID30652884
PMCPMC6449499
OpenAlexW2910882334

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.