ArticleJCO clinical cancer informatics2018
Distinct Phenotypic Clusters of Glioblastoma Growth and Response Kinetics Predict Survival.
Abstract readMulticenter Study
In one paragraph
Article in JCO clinical cancer informatics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- The logarithmic phase as a therapeutic direction: evaluating pharmacological strategies against cancer progression.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- DBSCAN applied to EHRs data from patients with glioblastoma clusters patients based on cytosolic Hsp70 protein, sex, and brain subventricular zone.BioData mining · 2026Article
- Do the benefits of IDH mutations in high-grade glioma persist beyond the first recurrence? A multi-institutional retrospective analysis.Journal of neuro-oncology · 2025Article
- Clustering Functional Magnetic Resonance Imaging Time Series in Glioblastoma Characterization: A Review of the Evolution, Applications, and Potentials.Brain sciences · 2024Review
- Exploring Monocytes-Macrophages in Immune Microenvironment of Glioblastoma for the Design of Novel Therapeutic Strategies.Brain sciences · 2023Review
- Novel Clinical Trial Designs in Neuro-Oncology.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Radiographic Response Assessment Strategies for Early-Phase Brain Trials in Complex Tumor Types and Drug Combinations: from Digital "Flipbooks" to Control Systems Theory.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Hypothetical generalized framework for a new imaging endpoint of therapeutic activity in early phase clinical trials in brain tumors.Neuro-oncology · 2022Article
- Enhanced Detection of Treatment Effects on Metastatic Colorectal Cancer with Volumetric CT Measurements for Tumor Burden Growth Rate Evaluation.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Article
- A Deep Convolutional Neural Network for Annotation of Magnetic Resonance Imaging Sequence Type.Journal of digital imaging · 2020Article
- Mathematical deconvolution of CAR T-cell proliferation and exhaustion from real-time killing assay data.Journal of the Royal Society, Interface · 2020Article
- Novel approaches for glioblastoma treatment: Focus on tumor heterogeneity, treatment resistance, and computational tools.Cancer reports (Hoboken, N.J.) · 2019Article
- Quantifying Uncertainty and Robustness in a Biomathematical Model-Based Patient-Specific Response Metric for Glioblastoma.JCO clinical cancer informatics · 2019Article
- The Novel Roles of Connexin Channels and Tunneling Nanotubes in Cancer Pathogenesis.International journal of molecular sciences · 2018Review
- Change in volumetric tumor growth rate after cytotoxic therapy is predictive of overall survival in recurrent glioblastoma.Neuro-oncology advancesArticle
- Therapeutic Response Assessment of High-Grade Gliomas During Early-Phase Drug Development in the Era of Molecular and Immunotherapies.Cancer journal (Sudbury, Mass.)Review
Corrections and comments
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Authors and funding
18 authors.
Corbin A RayfieldCorbin A. Rayfield, Fillan Grady, Gustavo De Leon, Eduardo Carrasco, Pamela Jackson, Mayur Vora, Sandra K. Johnston, Andrea Hawkins-Daarud, Kamala R. Clark-Swanson, Scott Whitmire, Mauricio E. Gamez, Alyx Porter, Leland Hu, Bernard Bendok, Sujay Vora, and Kristin R. Swanson, Mayo Clinic, Phoenix, AZ; Russell Rockne, Beckman Research Institute, City of Hope, Duarte, CA; and Sandra K. Johnston and Luis Gonzalez-Cuyar, University of Washington, Seattle, WA.
Fillan GradyCorbin A. Rayfield, Fillan Grady, Gustavo De Leon, Eduardo Carrasco, Pamela Jackson, Mayur Vora, Sandra K. Johnston, Andrea Hawkins-Daarud, Kamala R. Clark-Swanson, Scott Whitmire, Mauricio E. Gamez, Alyx Porter, Leland Hu, Bernard Bendok, Sujay Vora, and Kristin R. Swanson, Mayo Clinic, Phoenix, AZ; Russell Rockne, Beckman Research Institute, City of Hope, Duarte, CA; and Sandra K. Johnston and Luis Gonzalez-Cuyar, University of Washington, Seattle, WA.
Gustavo De LeonCorbin A. Rayfield, Fillan Grady, Gustavo De Leon, Eduardo Carrasco, Pamela Jackson, Mayur Vora, Sandra K. Johnston, Andrea Hawkins-Daarud, Kamala R. Clark-Swanson, Scott Whitmire, Mauricio E. Gamez, Alyx Porter, Leland Hu, Bernard Bendok, Sujay Vora, and Kristin R. Swanson, Mayo Clinic, Phoenix, AZ; Russell Rockne, Beckman Research Institute, City of Hope, Duarte, CA; and Sandra K. Johnston and Luis Gonzalez-Cuyar, University of Washington, Seattle, WA.
Russell RockneCorbin A. Rayfield, Fillan Grady, Gustavo De Leon, Eduardo Carrasco, Pamela Jackson, Mayur Vora, Sandra K. Johnston, Andrea Hawkins-Daarud, Kamala R. Clark-Swanson, Scott Whitmire, Mauricio E. Gamez, Alyx Porter, Leland Hu, Bernard Bendok, Sujay Vora, and Kristin R. Swanson, Mayo Clinic, Phoenix, AZ; Russell Rockne, Beckman Research Institute, City of Hope, Duarte, CA; and Sandra K. Johnston and Luis Gonzalez-Cuyar, University of Washington, Seattle, WA.
Eduardo CarrascoCorbin A. Rayfield, Fillan Grady, Gustavo De Leon, Eduardo Carrasco, Pamela Jackson, Mayur Vora, Sandra K. Johnston, Andrea Hawkins-Daarud, Kamala R. Clark-Swanson, Scott Whitmire, Mauricio E. Gamez, Alyx Porter, Leland Hu, Bernard Bendok, Sujay Vora, and Kristin R. Swanson, Mayo Clinic, Phoenix, AZ; Russell Rockne, Beckman Research Institute, City of Hope, Duarte, CA; and Sandra K. Johnston and Luis Gonzalez-Cuyar, University of Washington, Seattle, WA.
Pamela JacksonCorbin A. Rayfield, Fillan Grady, Gustavo De Leon, Eduardo Carrasco, Pamela Jackson, Mayur Vora, Sandra K. Johnston, Andrea Hawkins-Daarud, Kamala R. Clark-Swanson, Scott Whitmire, Mauricio E. Gamez, Alyx Porter, Leland Hu, Bernard Bendok, Sujay Vora, and Kristin R. Swanson, Mayo Clinic, Phoenix, AZ; Russell Rockne, Beckman Research Institute, City of Hope, Duarte, CA; and Sandra K. Johnston and Luis Gonzalez-Cuyar, University of Washington, Seattle, WA.
Mayur VoraCorbin A. Rayfield, Fillan Grady, Gustavo De Leon, Eduardo Carrasco, Pamela Jackson, Mayur Vora, Sandra K. Johnston, Andrea Hawkins-Daarud, Kamala R. Clark-Swanson, Scott Whitmire, Mauricio E. Gamez, Alyx Porter, Leland Hu, Bernard Bendok, Sujay Vora, and Kristin R. Swanson, Mayo Clinic, Phoenix, AZ; Russell Rockne, Beckman Research Institute, City of Hope, Duarte, CA; and Sandra K. Johnston and Luis Gonzalez-Cuyar, University of Washington, Seattle, WA.
Sandra K JohnstonCorbin A. Rayfield, Fillan Grady, Gustavo De Leon, Eduardo Carrasco, Pamela Jackson, Mayur Vora, Sandra K. Johnston, Andrea Hawkins-Daarud, Kamala R. Clark-Swanson, Scott Whitmire, Mauricio E. Gamez, Alyx Porter, Leland Hu, Bernard Bendok, Sujay Vora, and Kristin R. Swanson, Mayo Clinic, Phoenix, AZ; Russell Rockne, Beckman Research Institute, City of Hope, Duarte, CA; and Sandra K. Johnston and Luis Gonzalez-Cuyar, University of Washington, Seattle, WA.
Andrea Hawkins-DaarudCorbin A. Rayfield, Fillan Grady, Gustavo De Leon, Eduardo Carrasco, Pamela Jackson, Mayur Vora, Sandra K. Johnston, Andrea Hawkins-Daarud, Kamala R. Clark-Swanson, Scott Whitmire, Mauricio E. Gamez, Alyx Porter, Leland Hu, Bernard Bendok, Sujay Vora, and Kristin R. Swanson, Mayo Clinic, Phoenix, AZ; Russell Rockne, Beckman Research Institute, City of Hope, Duarte, CA; and Sandra K. Johnston and Luis Gonzalez-Cuyar, University of Washington, Seattle, WA.
Kamala R Clark-SwansonCorbin A. Rayfield, Fillan Grady, Gustavo De Leon, Eduardo Carrasco, Pamela Jackson, Mayur Vora, Sandra K. Johnston, Andrea Hawkins-Daarud, Kamala R. Clark-Swanson, Scott Whitmire, Mauricio E. Gamez, Alyx Porter, Leland Hu, Bernard Bendok, Sujay Vora, and Kristin R. Swanson, Mayo Clinic, Phoenix, AZ; Russell Rockne, Beckman Research Institute, City of Hope, Duarte, CA; and Sandra K. Johnston and Luis Gonzalez-Cuyar, University of Washington, Seattle, WA.
Scott WhitmireCorbin A. Rayfield, Fillan Grady, Gustavo De Leon, Eduardo Carrasco, Pamela Jackson, Mayur Vora, Sandra K. Johnston, Andrea Hawkins-Daarud, Kamala R. Clark-Swanson, Scott Whitmire, Mauricio E. Gamez, Alyx Porter, Leland Hu, Bernard Bendok, Sujay Vora, and Kristin R. Swanson, Mayo Clinic, Phoenix, AZ; Russell Rockne, Beckman Research Institute, City of Hope, Duarte, CA; and Sandra K. Johnston and Luis Gonzalez-Cuyar, University of Washington, Seattle, WA.
Mauricio E GamezCorbin A. Rayfield, Fillan Grady, Gustavo De Leon, Eduardo Carrasco, Pamela Jackson, Mayur Vora, Sandra K. Johnston, Andrea Hawkins-Daarud, Kamala R. Clark-Swanson, Scott Whitmire, Mauricio E. Gamez, Alyx Porter, Leland Hu, Bernard Bendok, Sujay Vora, and Kristin R. Swanson, Mayo Clinic, Phoenix, AZ; Russell Rockne, Beckman Research Institute, City of Hope, Duarte, CA; and Sandra K. Johnston and Luis Gonzalez-Cuyar, University of Washington, Seattle, WA.
Alyx PorterCorbin A. Rayfield, Fillan Grady, Gustavo De Leon, Eduardo Carrasco, Pamela Jackson, Mayur Vora, Sandra K. Johnston, Andrea Hawkins-Daarud, Kamala R. Clark-Swanson, Scott Whitmire, Mauricio E. Gamez, Alyx Porter, Leland Hu, Bernard Bendok, Sujay Vora, and Kristin R. Swanson, Mayo Clinic, Phoenix, AZ; Russell Rockne, Beckman Research Institute, City of Hope, Duarte, CA; and Sandra K. Johnston and Luis Gonzalez-Cuyar, University of Washington, Seattle, WA.
Leland HuCorbin A. Rayfield, Fillan Grady, Gustavo De Leon, Eduardo Carrasco, Pamela Jackson, Mayur Vora, Sandra K. Johnston, Andrea Hawkins-Daarud, Kamala R. Clark-Swanson, Scott Whitmire, Mauricio E. Gamez, Alyx Porter, Leland Hu, Bernard Bendok, Sujay Vora, and Kristin R. Swanson, Mayo Clinic, Phoenix, AZ; Russell Rockne, Beckman Research Institute, City of Hope, Duarte, CA; and Sandra K. Johnston and Luis Gonzalez-Cuyar, University of Washington, Seattle, WA.
Luis Gonzalez-CuyarCorbin A. Rayfield, Fillan Grady, Gustavo De Leon, Eduardo Carrasco, Pamela Jackson, Mayur Vora, Sandra K. Johnston, Andrea Hawkins-Daarud, Kamala R. Clark-Swanson, Scott Whitmire, Mauricio E. Gamez, Alyx Porter, Leland Hu, Bernard Bendok, Sujay Vora, and Kristin R. Swanson, Mayo Clinic, Phoenix, AZ; Russell Rockne, Beckman Research Institute, City of Hope, Duarte, CA; and Sandra K. Johnston and Luis Gonzalez-Cuyar, University of Washington, Seattle, WA.
Bernard BendokCorbin A. Rayfield, Fillan Grady, Gustavo De Leon, Eduardo Carrasco, Pamela Jackson, Mayur Vora, Sandra K. Johnston, Andrea Hawkins-Daarud, Kamala R. Clark-Swanson, Scott Whitmire, Mauricio E. Gamez, Alyx Porter, Leland Hu, Bernard Bendok, Sujay Vora, and Kristin R. Swanson, Mayo Clinic, Phoenix, AZ; Russell Rockne, Beckman Research Institute, City of Hope, Duarte, CA; and Sandra K. Johnston and Luis Gonzalez-Cuyar, University of Washington, Seattle, WA.
Sujay VoraCorbin A. Rayfield, Fillan Grady, Gustavo De Leon, Eduardo Carrasco, Pamela Jackson, Mayur Vora, Sandra K. Johnston, Andrea Hawkins-Daarud, Kamala R. Clark-Swanson, Scott Whitmire, Mauricio E. Gamez, Alyx Porter, Leland Hu, Bernard Bendok, Sujay Vora, and Kristin R. Swanson, Mayo Clinic, Phoenix, AZ; Russell Rockne, Beckman Research Institute, City of Hope, Duarte, CA; and Sandra K. Johnston and Luis Gonzalez-Cuyar, University of Washington, Seattle, WA.
Kristin R SwansonCorbin A. Rayfield, Fillan Grady, Gustavo De Leon, Eduardo Carrasco, Pamela Jackson, Mayur Vora, Sandra K. Johnston, Andrea Hawkins-Daarud, Kamala R. Clark-Swanson, Scott Whitmire, Mauricio E. Gamez, Alyx Porter, Leland Hu, Bernard Bendok, Sujay Vora, and Kristin R. Swanson, Mayo Clinic, Phoenix, AZ; Russell Rockne, Beckman Research Institute, City of Hope, Duarte, CA; and Sandra K. Johnston and Luis Gonzalez-Cuyar, University of Washington, Seattle, WA.
Funding
"Research Supplement to Promote Diversity in Health-Related Research", as part of Moffitt PS-OC, "Cancer as a Complex adaptive System"U54CA193489 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI ANDERSON, ALEXANDER ROBERTSON ALLAN, GATENBY, ROBERT A · 2015 to 2020
$12.5MTrans Network ProjectU54CA210180 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WHITE, FOREST M · 2016 to 2020
$10.2MThe Physi(ologi)cal Microenvironment and its Role in Tumor Invasion and MetastaseU54CA143970 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GATENBY, ROBERT A · 2009 to 2014
$9.3MPatient-specific predictive modeling that integrates advanced cancer imagingR01CA164371 · NCI · UNIVERSITY OF WASHINGTON · PI KINAHAN, PAUL E., SWANSON, KRISTIN R · 2011 to 2015
$4.5MQuantifying Multiscale Competitive Landscapes of Clonal Diversity in GlioblastomaU01CA220378 · NCI · MAYO CLINIC ARIZONA · PI HU, LELAND, SWANSON, KRISTIN R · 2017 to 2021
$4.3MNovel Tools for Evaluation and Prediction of Radiotherapy Response in IndividualR01NS060752 · NINDS · UNIVERSITY OF WASHINGTON · PI SWANSON, KRISTIN R · 2009 to 2013
$1.6MNCI NIH HHS R01 CA164371NCI NIH HHS U01 CA220378NCI NIH HHS U54 CA143970NCI NIH HHS U54 CA193489NCI NIH HHS U54 CA210180NINDS NIH HHS R01 NS060752
Abstract
purposeDespite the intra- and intertumoral heterogeneity seen in glioblastoma multiforme (GBM), there is little definitive data on the underlying cause of the differences in patient survivals. Serial imaging assessment of tumor growth allows quantification of tumor growth kinetics (TGK) measured in terms of changes in the velocity of radial expansion seen on imaging. Because a systematic study of this entire TGK phenotype-growth before treatment and during each treatment to recurrence -has never been coordinately studied in GBMs, we sought to identify whether patients cluster into discrete groups on the basis of their TGK. PATIENTS AND
methodsFrom our multi-institutional database, we identified 48 patients who underwent maximally safe resection followed by radiotherapy with imaging follow-up through the time of recurrence. The patients were then clustered into two groups through a k-means algorithm taking as input only the TGK before and during treatment.
resultsThere was a significant survival difference between the clusters ( P = .003). Paradoxically, patients among the long-lived cluster had significantly larger tumors at diagnosis ( P = .027) and faster growth before treatment ( P = .003) but demonstrated a better response to adjuvant chemotherapy ( P = .048). A predictive model was built to identify which cluster patients would likely fall into on the basis of information that would be available to clinicians immediately after radiotherapy (accuracy, 90.3%).
conclusionDichotomizing the heterogeneity of GBMs into two populations-one faster growing yet more responsive with increased survival and one slower growing yet less responsive with shorter survival-suggests that many patients who receive standard-of-care treatments may get better benefit from select alternative treatments.
Indexed as
AdultAgedBrainBrain NeoplasmsChemotherapy, AdjuvantCluster AnalysisFemaleGlioblastomaHumansKineticsMachine LearningMaleMiddle AgedPhenotypeProspective StudiesRadiotherapy, Adjuvant
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