ArticleJCO clinical cancer informatics2018
Structured Approach for Evaluating Strategies for Cancer Ascertainment Using Large-Scale Electronic Health Record Data.
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Article in JCO clinical cancer informatics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
6.8field-weighted citation impact, top 4% of its field
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Development and evaluation of a computable phenotype to identify pediatric patients with leukemia and lymphoma treated with chemotherapy using electronic health record data.Pediatric blood & cancer · 2019Trial
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- Improving colonoscopy quality in the national VA healthcare system.Contemporary clinical trials · 2025Article
- Use of disease modifying anti-rheumatic drugs and risk of multiple myeloma in US Veterans with rheumatoid arthritis.BMC rheumatology · 2025Article
- Recalibrating the Genetics and Epidemiology of Colorectal Cancer Consortium Environmental Risk Score for Use in US Veterans.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Impact of Helicobacter pylori Infection and Treatment on Colorectal Cancer in a Large, Nationwide Cohort.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Article
- Summary of Veterans Health Administration Cancer Data Sources.Journal of registry management · 2024Article
- Baseline Characteristics and Longitudinal Outcomes of Traditional Serrated Adenomas: A Cohort Study.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023Article
- A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories.Nature medicine · 2023Article
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- Performance of a rule-based semi-automated method to optimize chart abstraction for surveillance imaging among patients treated for non-small cell lung cancer.BMC medical informatics and decision making · 2022Article
- Ten or More Cumulative Lifetime Adenomas Are Associated with Increased Risk for Advanced Neoplasia and Colorectal Cancer.Digestive diseases and sciences · 2022Article
- Socioeconomic Disparities in Pancreas Cancer Resection and Survival in the Veterans Health Administration.Annals of surgical oncology · 2022Article
- A strategy for validation of variables derived from large-scale electronic health record data.Journal of biomedical informatics · 2021Article
- Data Matching to Support Analysis of Cancer Epidemiology Among Veterans Compared With Non-Veteran Populations-An Exemplar in Brain Tumors.JCO clinical cancer informatics · 2021Article
- Time to Colonoscopy After Abnormal Stool-Based Screening and Risk for Colorectal Cancer Incidence and Mortality.Gastroenterology · 2021Article
- Risk Factors for Early-Onset Colorectal Cancer.Gastroenterology · 2020Article
- Article
- Metformin Use and Pancreatic Cancer Survival among Non-Hispanic White and African American U.S. Veterans with Diabetes Mellitus.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
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Authors and funding
14 authors at 5 institutions in 5 countries.
Ashley EarlesAshley Earles, Ranier Bustamante, and Samir Gupta, Veterans Affairs (VA) San Diego Healthcare System; Lin Liu, Karen Messer, María Elena Martínez, James D. Murphy, and Samir Gupta, University of California San Diego, San Diego; Tonya Kaltenbach, San Francisco VA Medical Center; Tonya Kaltenbach, University of California San Francisco, San Francisco, CA; Pat Coke, Central Arkansas Veterans Healthcare System, Little Rock, AR; Julie Lynch and Andrew J. Gawron, VA Salt Lake City Health Care System; Andrew J. Gawron, University of Utah, Salt Lake City, UT; Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Durham VA Medical Center; and Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Duke University, Durham, NC.
Lin LiuAshley Earles, Ranier Bustamante, and Samir Gupta, Veterans Affairs (VA) San Diego Healthcare System; Lin Liu, Karen Messer, María Elena Martínez, James D. Murphy, and Samir Gupta, University of California San Diego, San Diego; Tonya Kaltenbach, San Francisco VA Medical Center; Tonya Kaltenbach, University of California San Francisco, San Francisco, CA; Pat Coke, Central Arkansas Veterans Healthcare System, Little Rock, AR; Julie Lynch and Andrew J. Gawron, VA Salt Lake City Health Care System; Andrew J. Gawron, University of Utah, Salt Lake City, UT; Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Durham VA Medical Center; and Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Duke University, Durham, NC.
Ranier BustamanteAshley Earles, Ranier Bustamante, and Samir Gupta, Veterans Affairs (VA) San Diego Healthcare System; Lin Liu, Karen Messer, María Elena Martínez, James D. Murphy, and Samir Gupta, University of California San Diego, San Diego; Tonya Kaltenbach, San Francisco VA Medical Center; Tonya Kaltenbach, University of California San Francisco, San Francisco, CA; Pat Coke, Central Arkansas Veterans Healthcare System, Little Rock, AR; Julie Lynch and Andrew J. Gawron, VA Salt Lake City Health Care System; Andrew J. Gawron, University of Utah, Salt Lake City, UT; Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Durham VA Medical Center; and Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Duke University, Durham, NC.
Pat CokeAshley Earles, Ranier Bustamante, and Samir Gupta, Veterans Affairs (VA) San Diego Healthcare System; Lin Liu, Karen Messer, María Elena Martínez, James D. Murphy, and Samir Gupta, University of California San Diego, San Diego; Tonya Kaltenbach, San Francisco VA Medical Center; Tonya Kaltenbach, University of California San Francisco, San Francisco, CA; Pat Coke, Central Arkansas Veterans Healthcare System, Little Rock, AR; Julie Lynch and Andrew J. Gawron, VA Salt Lake City Health Care System; Andrew J. Gawron, University of Utah, Salt Lake City, UT; Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Durham VA Medical Center; and Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Duke University, Durham, NC.
Julie LynchAshley Earles, Ranier Bustamante, and Samir Gupta, Veterans Affairs (VA) San Diego Healthcare System; Lin Liu, Karen Messer, María Elena Martínez, James D. Murphy, and Samir Gupta, University of California San Diego, San Diego; Tonya Kaltenbach, San Francisco VA Medical Center; Tonya Kaltenbach, University of California San Francisco, San Francisco, CA; Pat Coke, Central Arkansas Veterans Healthcare System, Little Rock, AR; Julie Lynch and Andrew J. Gawron, VA Salt Lake City Health Care System; Andrew J. Gawron, University of Utah, Salt Lake City, UT; Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Durham VA Medical Center; and Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Duke University, Durham, NC.
Karen MesserAshley Earles, Ranier Bustamante, and Samir Gupta, Veterans Affairs (VA) San Diego Healthcare System; Lin Liu, Karen Messer, María Elena Martínez, James D. Murphy, and Samir Gupta, University of California San Diego, San Diego; Tonya Kaltenbach, San Francisco VA Medical Center; Tonya Kaltenbach, University of California San Francisco, San Francisco, CA; Pat Coke, Central Arkansas Veterans Healthcare System, Little Rock, AR; Julie Lynch and Andrew J. Gawron, VA Salt Lake City Health Care System; Andrew J. Gawron, University of Utah, Salt Lake City, UT; Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Durham VA Medical Center; and Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Duke University, Durham, NC.
María Elena MartínezAshley Earles, Ranier Bustamante, and Samir Gupta, Veterans Affairs (VA) San Diego Healthcare System; Lin Liu, Karen Messer, María Elena Martínez, James D. Murphy, and Samir Gupta, University of California San Diego, San Diego; Tonya Kaltenbach, San Francisco VA Medical Center; Tonya Kaltenbach, University of California San Francisco, San Francisco, CA; Pat Coke, Central Arkansas Veterans Healthcare System, Little Rock, AR; Julie Lynch and Andrew J. Gawron, VA Salt Lake City Health Care System; Andrew J. Gawron, University of Utah, Salt Lake City, UT; Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Durham VA Medical Center; and Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Duke University, Durham, NC.
James D MurphyAshley Earles, Ranier Bustamante, and Samir Gupta, Veterans Affairs (VA) San Diego Healthcare System; Lin Liu, Karen Messer, María Elena Martínez, James D. Murphy, and Samir Gupta, University of California San Diego, San Diego; Tonya Kaltenbach, San Francisco VA Medical Center; Tonya Kaltenbach, University of California San Francisco, San Francisco, CA; Pat Coke, Central Arkansas Veterans Healthcare System, Little Rock, AR; Julie Lynch and Andrew J. Gawron, VA Salt Lake City Health Care System; Andrew J. Gawron, University of Utah, Salt Lake City, UT; Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Durham VA Medical Center; and Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Duke University, Durham, NC.
Christina D WilliamsAshley Earles, Ranier Bustamante, and Samir Gupta, Veterans Affairs (VA) San Diego Healthcare System; Lin Liu, Karen Messer, María Elena Martínez, James D. Murphy, and Samir Gupta, University of California San Diego, San Diego; Tonya Kaltenbach, San Francisco VA Medical Center; Tonya Kaltenbach, University of California San Francisco, San Francisco, CA; Pat Coke, Central Arkansas Veterans Healthcare System, Little Rock, AR; Julie Lynch and Andrew J. Gawron, VA Salt Lake City Health Care System; Andrew J. Gawron, University of Utah, Salt Lake City, UT; Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Durham VA Medical Center; and Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Duke University, Durham, NC.
Deborah A FisherAshley Earles, Ranier Bustamante, and Samir Gupta, Veterans Affairs (VA) San Diego Healthcare System; Lin Liu, Karen Messer, María Elena Martínez, James D. Murphy, and Samir Gupta, University of California San Diego, San Diego; Tonya Kaltenbach, San Francisco VA Medical Center; Tonya Kaltenbach, University of California San Francisco, San Francisco, CA; Pat Coke, Central Arkansas Veterans Healthcare System, Little Rock, AR; Julie Lynch and Andrew J. Gawron, VA Salt Lake City Health Care System; Andrew J. Gawron, University of Utah, Salt Lake City, UT; Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Durham VA Medical Center; and Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Duke University, Durham, NC.
Dawn T ProvenzaleAshley Earles, Ranier Bustamante, and Samir Gupta, Veterans Affairs (VA) San Diego Healthcare System; Lin Liu, Karen Messer, María Elena Martínez, James D. Murphy, and Samir Gupta, University of California San Diego, San Diego; Tonya Kaltenbach, San Francisco VA Medical Center; Tonya Kaltenbach, University of California San Francisco, San Francisco, CA; Pat Coke, Central Arkansas Veterans Healthcare System, Little Rock, AR; Julie Lynch and Andrew J. Gawron, VA Salt Lake City Health Care System; Andrew J. Gawron, University of Utah, Salt Lake City, UT; Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Durham VA Medical Center; and Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Duke University, Durham, NC.
Andrew J GawronAshley Earles, Ranier Bustamante, and Samir Gupta, Veterans Affairs (VA) San Diego Healthcare System; Lin Liu, Karen Messer, María Elena Martínez, James D. Murphy, and Samir Gupta, University of California San Diego, San Diego; Tonya Kaltenbach, San Francisco VA Medical Center; Tonya Kaltenbach, University of California San Francisco, San Francisco, CA; Pat Coke, Central Arkansas Veterans Healthcare System, Little Rock, AR; Julie Lynch and Andrew J. Gawron, VA Salt Lake City Health Care System; Andrew J. Gawron, University of Utah, Salt Lake City, UT; Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Durham VA Medical Center; and Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Duke University, Durham, NC.
Tonya KaltenbachAshley Earles, Ranier Bustamante, and Samir Gupta, Veterans Affairs (VA) San Diego Healthcare System; Lin Liu, Karen Messer, María Elena Martínez, James D. Murphy, and Samir Gupta, University of California San Diego, San Diego; Tonya Kaltenbach, San Francisco VA Medical Center; Tonya Kaltenbach, University of California San Francisco, San Francisco, CA; Pat Coke, Central Arkansas Veterans Healthcare System, Little Rock, AR; Julie Lynch and Andrew J. Gawron, VA Salt Lake City Health Care System; Andrew J. Gawron, University of Utah, Salt Lake City, UT; Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Durham VA Medical Center; and Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Duke University, Durham, NC.
Samir GuptaAshley Earles, Ranier Bustamante, and Samir Gupta, Veterans Affairs (VA) San Diego Healthcare System; Lin Liu, Karen Messer, María Elena Martínez, James D. Murphy, and Samir Gupta, University of California San Diego, San Diego; Tonya Kaltenbach, San Francisco VA Medical Center; Tonya Kaltenbach, University of California San Francisco, San Francisco, CA; Pat Coke, Central Arkansas Veterans Healthcare System, Little Rock, AR; Julie Lynch and Andrew J. Gawron, VA Salt Lake City Health Care System; Andrew J. Gawron, University of Utah, Salt Lake City, UT; Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Durham VA Medical Center; and Christina D. Williams, Deborah A. Fisher, and Dawn T. Provenzale, Duke University, Durham, NC.
AstraZeneca (Poland) · PLMyriad (Germany) · DEAstellas Pharma (China) · CNBoehringer Ingelheim (France) · FRExact Sciences (United States) · US
Funding
Optimizing Colorectal Cancer and Polyp Surveillance after Colorectal PolypectomyI01HX001574 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI GUPTA, SAMIR · 2015 to 2019
–HSRD VA I01 HX001574
Abstract
purposeCancer ascertainment using large-scale electronic health records is a challenge. Our aim was to propose and apply a structured approach for evaluating multiple candidate approaches for cancer ascertainment using colorectal cancer (CRC) ascertainment within the US Department of Veterans Affairs (VA) as a use case.
methodsThe proposed approach for evaluating cancer ascertainment strategies includes assessment of individual strategy performance, comparison of agreement across strategies, and review of discordant diagnoses. We applied this approach to compare three strategies for CRC ascertainment within the VA: administrative claims data consisting of International Classification of Diseases, Ninth Revision (ICD9) diagnosis codes; the VA Central Cancer Registry (VACCR); and the newly accessible Oncology Domain, consisting of cases abstracted by local cancer registrars. The study sample consisted of 1,839,043 veterans with index colonoscopy performed from 1999 to 2014. Strategy-specific performance was estimated based on manual record review of 100 candidate CRC cases and 100 colonoscopy controls. Strategies were further compared using Cohen's κ and focused review of discordant CRC diagnoses.
resultsA total of 92,197 individuals met at least one CRC definition. All three strategies had high sensitivity and specificity for incident CRC. However, the ICD9-based strategy demonstrated poor positive predictive value (58%). VACCR and Oncology Domain had almost perfect agreement with each other (κ, 0.87) but only moderate agreement with ICD9-based diagnoses (κ, 0.51 and 0.57, respectively). Among discordant cases reviewed, 15% of ICD9-positive but VACCR- or Oncology Domain-negative cases had incident CRC.
conclusionEvaluating novel strategies for identifying cancer requires a structured approach, including validation against manual record review, agreement among candidate strategies, and focused review of discordant findings. Without careful assessment of ascertainment methods, analyses may be subject to bias and limited in clinical impact.
Indexed as
Administrative Claims, HealthcareAgedColonoscopyColorectal NeoplasmsElectronic Health RecordsFemaleHumansInternational Classification of DiseasesMaleMiddle AgedRegistriesUnited StatesUnited States Department of Veterans Affairs
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