Evidence map›Paper›PMID 30652526›Full record

ArticleTissue engineering. Part A2019

Development of Intestinal Scaffolds that Mimic Native Mammalian Intestinal Tissue.

Mitchell R Ladd, Cait M Costello, Carolyn Gosztyla, Adam D Werts, Blake Johnson, William B Fulton, Laura Y Martin, Elizabeth J Redfield, Bryan Crawford, Rohan Panaparambil and 3 more

Open access · greenAbstract read
In one paragraph

Article in Tissue engineering. Part A, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Next-Generation Therapies for Gastrointestinal Repair: Converging Traditional Medicine and Tissue Engineering.JGH open : an open access journal of gastroenterology and hepatology · 2025
    Review
  5. Review
  6. Tissue Engineering for Gastrointestinal and Genitourinary Tracts.International journal of molecular sciences · 2022
    Review
  7. Degradation of P(3HB-Polymers · 2022
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Building Scaffolds for Tubular Tissue Engineering.Frontiers in bioengineering and biotechnology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Mitchell R LaddDepartment of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland.
Cait M CostelloDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, New York.
Carolyn GosztylaDepartment of Surgery, Walter Reed National Military Medical Center, Bethesda, Maryland.
Adam D WertsDepartment of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland.
Blake JohnsonDepartment of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland.
William B FultonDepartment of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland.
Laura Y MartinDepartment of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland.
Elizabeth J RedfieldDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, New York.
Bryan CrawfordDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland.
Rohan PanaparambilDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.
Chhinder P SodhiDepartment of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland.
John C MarchDepartment of Biological and Environmental Engineering, Cornell University, Ithaca, New York.
David J HackamDepartment of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland.
Johns Hopkins University · USCornell University · USJohns Hopkins Medicine · USWalter Reed National Military Medical Center · US

Funding

Training Veterinarians for Careers in Biomedical ResearchT32OD011089 · OD · JOHNS HOPKINS UNIVERSITY · PI JOSEPH L MANKOWSKI · 2012 to 2026
$6.7M
Clinical and Laboratory Research Training for Gastrointestinal SurgeonsT32DK007713 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DAVID J HACKAM · 1996 to 2026
$5.2M
TLR4 Signaling in the Pathogenesis of Surgical Necrotizing EnterocolitisR01GM078238 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HACKAM, DAVID J · 2006 to 2019
$3.9M
Modulation of TLR4 and TLR9 Signaling in NECR01DK083752 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HACKAM, DAVID J · 2008 to 2016
$3.4M
Maternal-Fetal AHR Signaling in the Pathogenesis and Treatment of Necrotizing EnterocolitisR01DK117186 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HACKAM, DAVID J · 2018 to 2021
$1.5M
NIDDK NIH HHS R01 DK083752NIDDK NIH HHS R01 DK117186NIDDK NIH HHS T32 DK007713NIGMS NIH HHS R01 GM078238NIH HHS T32 OD011089
6 · The paper itself

Abstract

impact statementThis study is significant because it demonstrates an attempt to design a scaffold specifically for small intestine using a novel fabrication method, resulting in an architecture that resembles intestinal villi. In addition, we use the versatile polymer poly(glycerol sebacate) (PGS) for artificial intestine, which has tunable mechanical and degradation properties that can be harnessed for further fine-tuning of scaffold design. Moreover, the utilization of PGS allows for future development of growth factor and drug delivery from the scaffolds to promote artificial intestine formation.

Indexed as

AnimalsBiocompatible MaterialsDecanoatesGlycerolImmunohistochemistryIntestinesMaleMiceMice, Inbred C57BLMicroscopy, Electron, ScanningPolymersSwineTissue EngineeringTissue ScaffoldsBiocompatible MaterialsDecanoatesGlycerolpoly(glycerol-sebacate)Polymersartificial intestinebiodegradable polymersfunctional tissue engineering with intestinal scaffoldsintestinal tissue engineeringpoly(glycerol sebacate) scaffold biomechanicsshort bowel syndrome

Identifiers

PMID30652526
PMCPMC6760185
OpenAlexW2908522764

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.