Evidence map›Paper›PMID 30652496›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2019

Acute and chronic changes in the control of breathing in a rat model of bronchopulmonary dysplasia.

Gary C Mouradian, Santiago Alvarez-Argote, Ryan Gorzek, Gabriel Thuku, Teresa Michkalkiewicz, Margaret T T Wong-Riley, Girija Ganesh Konduri, Matthew R Hodges

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Titrating cumulative neonatal hyperoxia in mice to model bronchopulmonary dysplasia severities.American journal of respiratory cell and molecular biology · 2026
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  5. Methods for the ComprehensiveFrontiers in physiology · 2022
    Article
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  8. Perinatal Hypoxemia and Oxygen Sensing.Comprehensive Physiology · 2021
    Article
  9. TRIM72 mediates lung epithelial cell death upon hyperoxia exposure.Journal of the Chinese Medical Association : JCMA · 2021
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Gary C MouradianDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Santiago Alvarez-ArgoteDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Ryan GorzekDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Gabriel ThukuDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Teresa MichkalkiewiczDepartment of Pediatrics, Medical College of Wisconsin , Milwaukee, Wisconsin.
Margaret T T Wong-RileyDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin , Milwaukee, Wisconsin.
Girija Ganesh KonduriDepartment of Pediatrics, Medical College of Wisconsin , Milwaukee, Wisconsin.
Matthew R HodgesDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Medical College of Wisconsin · USChildren's Hospital of Wisconsin · US

Funding

Progressive seizure-induced cardiorespiratory dysfunction in a novel mutant rat model of seizure disorderR01HL122358 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HODGES, MATTHEW ROBERT · 2015 to 2024
$4.3M
AMP Kinase regulation in persistent pulmonary hypertension of the newbornR01HL136597 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI KONDURI, GIRIJA G. · 2018 to 2021
$1.5M
NHLBI NIH HHS R01 HL122358NHLBI NIH HHS R01 HL136597
6 · The paper itself

Abstract

Infants born very prematurely (<28 wk gestation) have immature lungs and often require supplemental oxygen. However, long-term hyperoxia exposure can arrest lung development, leading to bronchopulmonary dysplasia (BPD), which increases acute and long-term respiratory morbidity and mortality. The neural mechanisms controlling breathing are highly plastic during development. Whether the ventilatory control system adapts to pulmonary disease associated with hyperoxia exposure in infancy remains unclear. Here, we assessed potential age-dependent adaptations in the control of breathing in an established rat model of BPD associated with hyperoxia. Hyperoxia exposure (

Indexed as

Age FactorsAnimalsBronchopulmonary DysplasiaDisease Models, AnimalHyperoxiaHypertension, PulmonaryHypoxiaLungLung InjuryRatsbronchpulmonary dysplasiachronic hyperxoiahyperoxiarespiratory controlventilator control

Identifiers

PMID30652496
PMCPMC6459293
OpenAlexW2908749148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.