Evidence map›Paper›PMID 30652474›Full record

ArticleACS infectious diseases2019

Investigation of ( S)-(-)-Acidomycin: A Selective Antimycobacterial Natural Product That Inhibits Biotin Synthase.

Matthew R Bockman, Curtis A Engelhart, Julia D Cramer, Michael D Howe, Neeraj K Mishra, Matthew Zimmerman, Peter Larson, Nadine Alvarez-Cabrera, Sae Woong Park, Helena I M Boshoff and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

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  11. Screening of Microbial Fermentation Products for Anti-Animals : an open access journal from MDPI · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 1 country.

Matthew R BockmanDepartment of Medicinal Chemistry , University of Minnesota , 308 Harvard Street SE , Minneapolis , Minnesota 55455 , United States.
Curtis A EngelhartDepartment of Microbiology and Immunology , Weill Cornell Medical College , 1300 York Avenue , New York , New York 10021 , United States.
Julia D CramerDepartment of Chemistry , University of Hawaii at Manoa , 2545 McCarthy Mall , Honolulu , Hawaii 96822 , United States.
Michael D HoweDepartment of Medicinal Chemistry , University of Minnesota , 308 Harvard Street SE , Minneapolis , Minnesota 55455 , United States.
Neeraj K MishraDepartment of Medicinal Chemistry , University of Minnesota , 308 Harvard Street SE , Minneapolis , Minnesota 55455 , United States.
Matthew ZimmermanPublic Health Research Institute , Rutgers, The State University of New Jersey , 225 Warren Street , Newark , New Jersey 07103 , United States.
Peter LarsonDepartment of Medicinal Chemistry , University of Minnesota , 308 Harvard Street SE , Minneapolis , Minnesota 55455 , United States.
Nadine Alvarez-CabreraPublic Health Research Institute , Rutgers, The State University of New Jersey , 225 Warren Street , Newark , New Jersey 07103 , United States.
Sae Woong ParkDepartment of Microbiology and Immunology , Weill Cornell Medical College , 1300 York Avenue , New York , New York 10021 , United States.
Helena I M BoshoffTuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology , NIAID, NIH , 5601 Fishers Lane , Bethesda , Maryland 20892 , United States.ORCID 0000-0002-4333-206X
James M BeanSloan Kettering Institute , Memorial Sloan Kettering Cancer Center , 1275 York Avenue , New York , New York 10065 , United States.
Victor G YoungX-Ray Crystallographic Laboratory, LeClaire-Dow Chemical Instrumentation Facility, Department of Chemistry , University of Minnesota , 207 Pleasant Street SE , Minneapolis , Minnesota 55455 , United States.
David M FergusonDepartment of Medicinal Chemistry , University of Minnesota , 308 Harvard Street SE , Minneapolis , Minnesota 55455 , United States.ORCID 0000-0001-6294-8057
Veronique DartoisPublic Health Research Institute , Rutgers, The State University of New Jersey , 225 Warren Street , Newark , New Jersey 07103 , United States.
Joseph T JarrettDepartment of Chemistry , University of Hawaii at Manoa , 2545 McCarthy Mall , Honolulu , Hawaii 96822 , United States.
Dirk SchnappingerDepartment of Microbiology and Immunology , Weill Cornell Medical College , 1300 York Avenue , New York , New York 10021 , United States.
Courtney C AldrichDepartment of Medicinal Chemistry , University of Minnesota , 308 Harvard Street SE , Minneapolis , Minnesota 55455 , United States.ORCID 0000-0001-9261-594X
University of Minnesota · USCornell University · USRutgers, The State University of New Jersey · USUniversity of Hawaiʻi at Mānoa · USMemorial Sloan Kettering Cancer Center · USNational Institutes of Health · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Development Of New Chemotherapeutics For TuberculosisZIAAI000693 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BARRY, CLIFTON · 2009 to 2025
$20.1M
PATHOGENIC MECHANISMS OF MYCOBACTERIUM TUBERCULOSISZ01AI000693 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI BARRY, CLIFTON · 1993 to 2008
$8.1M
Biotin synthesis and biotin ligation in MtbR01AI091790 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHNAPPINGER, DIRK · 2011 to 2015
$3.0M
A QTRAP 6500 LC-MS/MS System from SCIEX for high accuracy drug content analysisS10OD023524 · OD · RBHS-NEW JERSEY MEDICAL SCHOOL · PI DARTOIS, VERONIQUE · 2017 to 2017
$526k
iTC200 MicroCalorimetry Cell Control UnitS10OD017982 · OD · UNIVERSITY OF MINNESOTA · PI ALDRICH, COURTNEY C · 2014 to 2014
$94k
Intramural NIH HHS Z01 AI000693Intramural NIH HHS Z99 AI999999NCI NIH HHS P30 CA008748NIAID NIH HHS R01 AI091790NIH HHS S10 OD017982NIH HHS S10 OD023524
6 · The paper itself

Abstract

The synthesis, absolute stereochemical configuration, complete biological characterization, mechanism of action and resistance, and pharmacokinetic properties of ( S)-(-)-acidomycin are described. Acidomycin possesses promising antitubercular activity against a series of contemporary drug susceptible and drug-resistant M. tuberculosis strains (minimum inhibitory concentrations (MICs) = 0.096-6.2 μM) but is inactive against nontuberculosis mycobacteria and Gram-positive and Gram-negative pathogens (MICs > 1000 μM). Complementation studies with biotin biosynthetic pathway intermediates and subsequent biochemical studies confirmed acidomycin inhibits biotin synthesis with a K

Indexed as

AnimalsAntitubercular AgentsBacterial ProteinsBiological ProductsBiotinCaproatesDrug Resistance, BacterialHumansKineticsMiceMicrobial Sensitivity TestsMycobacterium tuberculosisSulfurtransferasesThiazolidinesTuberculosisAntitubercular AgentsBacterial ProteinsBiological ProductsBiotinbiotin synthetaseCaproatesmycobacidinSulfurtransferasesThiazolidinesaccumulationacidomycinantimetabolitebiotin biosynthesisbiotin synthaseMycobacterium tuberculosistuberculosis

Identifiers

PMID30652474
PMCPMC6724193
OpenAlexW2910883017

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.