Evidence map›Paper›PMID 30652420›Full record

ArticlePhysiological reports2019

Dynamic cerebral autoregulation is attenuated in young fit women.

Lawrence Labrecque, Kevan Rahimaly, Sarah Imhoff, Myriam Paquette, Olivier Le Blanc, Simon Malenfant, Audrey Drapeau, Jonathan D Smirl, Damian M Bailey, Patrice Brassard

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

  1. A systematic review, meta-analysisJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
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  14. APOE4 carriers display loss of anticipatory cerebrovascular regulation across the Alzheimer's disease continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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  19. The effect of hypercapnia on the directional sensitivity of dynamic cerebral autoregulation and the influence of age and sex.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Lawrence LabrecqueDepartment of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.
Kevan RahimalyDepartment of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.
Sarah ImhoffDepartment of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.
Myriam PaquetteDepartment of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.
Olivier Le BlancDepartment of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.
Simon MalenfantDepartment of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.
Audrey DrapeauDepartment of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.
Jonathan D SmirlConcussion Research Laboratory, Health and Exercise Sciences, University of British Columbia Okanagan, British Columbia, Canada.
Damian M BaileyNeurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, South Wales, United Kingdom.ORCID 0000-0003-0498-7095
Patrice BrassardDepartment of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.ORCID 0000-0002-6254-5044
Institut universitaire de cardiologie et de pneumologie de Québec · CAUniversity of British Columbia · CAUniversity of South Wales · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Young women exhibit higher prevalence of orthostatic hypotension with presyncopal symptoms compared to men. These symptoms could be influenced by an attenuated ability of the cerebrovasculature to respond to rapid blood pressure (BP) changes [dynamic cerebral autoregulation (dCA)]. The influence of sex on dCA remains unclear. dCA in 11 fit women (25 ± 2 years) and 11 age-matched men (24 ± 1 years) was compared using a multimodal approach including a sit-to-stand (STS) and forced BP oscillations (repeated squat-stand performed at 0.05 and 0.10 Hz). Prevalence of initial orthostatic hypotension (IOH; decrease in systolic ≥ 40 mmHg and/or diastolic BP ≥ 20 mmHg) during the first 15 sec of STS was determined as a functional outcome. In women, the decrease in mean middle cerebral artery blood velocity (MCAv

Indexed as

AdultBlood Flow VelocityBlood PressureCerebrovascular CirculationFemaleHemodynamicsHomeostasisHumansHypotension, OrthostaticMaleMiddle Cerebral ArteryPhysical FitnessRandom AllocationSex FactorsYoung AdultBraincerebral blood flowcerebral pressure-flow relationshipdynamic cerebral autoregulationsex differences

Identifiers

PMID30652420
PMCPMC6335382
OpenAlexW2910937542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.