Evidence map›Paper›PMID 30652259›Full record

ArticleNeurochemical research2019

Carvacrol Depends on Heme Oxygenase-1 (HO-1) to Exert Antioxidant, Anti-inflammatory, and Mitochondria-Related Protection in the Human Neuroblastoma SH-SY5Y Cells Line Exposed to Hydrogen Peroxide.

Aline Lukasievicz Chenet, Adriane Ribeiro Duarte, Fhelipe Jolner Souza de Almeida, Cláudia Marlise Balbinotti Andrade, Marcos Roberto de Oliveira

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

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  5. Antioxidants (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Aline Lukasievicz ChenetGrupo de Estudos em Neuroquímica e Neurobiologia de Moléculas Bioativas, Universidade Federal de Mato Grosso (UFMT), Av. Fernando Corrêa da Costa, 2367, Cuiaba, MT, CEP 78060-900, Brazil.
Adriane Ribeiro DuarteGrupo de Estudos em Neuroquímica e Neurobiologia de Moléculas Bioativas, Universidade Federal de Mato Grosso (UFMT), Av. Fernando Corrêa da Costa, 2367, Cuiaba, MT, CEP 78060-900, Brazil.
Fhelipe Jolner Souza de AlmeidaGrupo de Estudos em Neuroquímica e Neurobiologia de Moléculas Bioativas, Universidade Federal de Mato Grosso (UFMT), Av. Fernando Corrêa da Costa, 2367, Cuiaba, MT, CEP 78060-900, Brazil.
Cláudia Marlise Balbinotti AndradeGrupo de Estudos em Neuroquímica e Neurobiologia de Moléculas Bioativas, Universidade Federal de Mato Grosso (UFMT), Av. Fernando Corrêa da Costa, 2367, Cuiaba, MT, CEP 78060-900, Brazil.
Marcos Roberto de OliveiraGrupo de Estudos em Neuroquímica e Neurobiologia de Moléculas Bioativas, Universidade Federal de Mato Grosso (UFMT), Av. Fernando Corrêa da Costa, 2367, Cuiaba, MT, CEP 78060-900, Brazil. mrobioq@gmail.com.
Universidade Federal de Mato Grosso · BR

Funding

CAPES Bolsa de mestrado 2017-2019CNPq Edital Universal 2016; 400216/2016-7FAPEMAT Edital Universal 222541/2015
6 · The paper itself

Abstract

The link between mitochondrial dysfunction, redox impairment, and inflammation leads to increased rates of brain cells loss in neurodegenerative diseases and in affective disorders. Carvacrol (CAR) is a component of essential oils found in Labiatae. CAR exerts antioxidant and anti-inflammatory effects in different cell types, as assessed in both in vitro and in vivo experimental designs. Nonetheless, it was not previously investigated whether and how CAR would prevent mitochondrial impairment in human cells exposed to a pro-oxidant challenge. Therefore, we analyzed here whether a pretreatment (for 4 h) with CAR (10-1000 µM) would promote mitochondrial protection in the human neuroblastoma cells SH-SY5Y exposed to hydrogen peroxide (H

Indexed as

Anti-Inflammatory AgentsAntioxidantsCell Line, TumorCell SurvivalCymenesCytoprotectionDose-Response Relationship, DrugHeme Oxygenase-1HumansHydrogen PeroxideMitochondriaMonoterpenesAnti-Inflammatory AgentsAntioxidantscarvacrolCymenesHeme Oxygenase-1HMOX1 protein, humanHydrogen PeroxideMonoterpenesAnti-inflammatoryAntioxidantBioenergeticsCarvacrolHO-1Mitochondria

Identifiers

PMID30652259
OpenAlexW2910511698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.