Evidence map›Paper›PMID 30652238›Full record

ArticleInternational journal of hematology2019

Association of high levels of plasma OX40 with acute adult T-cell leukemia.

Yuetsu Tanaka, Yoshiaki Takahashi, Reiko Tanaka, Takuya Miyagi, Mineki Saito, Takuya Fukushima

Abstract read
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In one paragraph

Article in International journal of hematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yuetsu TanakaDepartment of Immunology, Graduate School of Medicine, University of the Ryukyus, Uehara 208, Nishihara-cho, Nakagami-gun, Okinawa, 903-0215, Japan. yuetsu@s4.dion.ne.jp.ORCID http://orcid.org/0000-0002-4845-2810
Yoshiaki TakahashiDepartment of Immunology, Graduate School of Medicine, University of the Ryukyus, Uehara 208, Nishihara-cho, Nakagami-gun, Okinawa, 903-0215, Japan.
Reiko TanakaDepartment of Immunology, Graduate School of Medicine, University of the Ryukyus, Uehara 208, Nishihara-cho, Nakagami-gun, Okinawa, 903-0215, Japan.
Takuya MiyagiDepartment of Immunology, Graduate School of Medicine, University of the Ryukyus, Uehara 208, Nishihara-cho, Nakagami-gun, Okinawa, 903-0215, Japan.
Mineki SaitoDepartment of Microbiology, Kawasaki Medical School, Okayama, Japan.
Takuya FukushimaLaboratory of Hematoimmunology, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
University of the Ryukyus · JPKawasaki Medical School · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

OX40, a member of the tumor necrosis factor receptor (TNFR) superfamily, co-stimulates activated T cells following interaction with its own ligand OX40L. Human T-cell leukemia virus type-1 (HTLV-1) is an etiological agent of adult T-cell leukemia (ATL). ATL cells are known to express cell surface OX40; however, the level of soluble OX40 (sOX40) in blood samples from ATL patients is unknown. Quantitative enzyme-linked immune-sorbent assay (ELISA) showed that sOX40 levels were significantly higher in plasma from acute ATL patients than those from asymptomatic HTLV-1 carriers and healthy donors, and correlated with sCD25 levels and HTLV-1 proviral loads in peripheral blood mononuclear cells (PBMCs). Fresh PBMCs from acute ATL patients showed a higher percentage of OX40-positive cells compared with those from carriers, and shed sOX40 into culture supernatants. Shedding of sOX40 was partially inhibited by a matrix metalloproteinase (MMP) inhibitor, GM6001. A fraction of sOX40 was capable of binding to OX40L. These results suggest that high levels of sOX40 are shed into blood from a large number of ATL cells in acute ATL patients. Thus, abnormally elevated plasma sOX40 levels may be useful as an additional diagnostic marker of acute ATL.

Indexed as

Human T-lymphotropic virus 1AnimalsBiomarkers, TumorCell Line, TumorDipeptidesEnzyme-Linked Immunosorbent AssayHumansLeukemia-Lymphoma, Adult T-CellMiceMice, SCIDNeoplasm ProteinsReceptors, OX40Biomarkers, TumorDipeptidesN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamideNeoplasm ProteinsReceptors, OX40TNFRSF4 protein, humanATLHTLV-1OX40Tax

Identifiers

PMID30652238
OpenAlexW2910009081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.