Evidence map›Paper›PMID 30652062›Full record

ArticleChemistryOpen2019

Development of XIAP Antagonists Based On De Novo 8,5-Fused Bicyclic Lactams.

Zhaojun J Sheng, Yiming M Shi, Ximing Xu, Sébastien Bellynck, Kun Zhang, Zhiyun Y Du, Xuetao Xu, François Maurel, Chang-Zhi Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemistryOpen, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhaojun J ShengInterfaces, Traitements, Organisation et Dynamique des Systemes (ITODYS) UMR 7086 CNRS Université Paris Diderot, Sorbonne Paris Cité 75205 Paris France.
Yiming M ShiInterfaces, Traitements, Organisation et Dynamique des Systemes (ITODYS) UMR 7086 CNRS Université Paris Diderot, Sorbonne Paris Cité 75205 Paris France.
Ximing XuSchool of Electrical and Information Engineering Institute of Bioinformatics and Medical Engineering Jiangsu University of Technology 213001 Changzhou China.
Sébastien BellynckInterfaces, Traitements, Organisation et Dynamique des Systemes (ITODYS) UMR 7086 CNRS Université Paris Diderot, Sorbonne Paris Cité 75205 Paris France.
Kun ZhangSchool of Chemical Engineering and Light Industry Institute of Natural Medicine and Green Chemistry Guangdong University of Technology 510006 Guangzhou China.
Zhiyun Y DuSchool of Chemical Engineering and Light Industry Institute of Natural Medicine and Green Chemistry Guangdong University of Technology 510006 Guangzhou China.
Xuetao XuSchool of Chemical and Environment Engineering Wuyi University 529020 Jiangmen China.
François MaurelInterfaces, Traitements, Organisation et Dynamique des Systemes (ITODYS) UMR 7086 CNRS Université Paris Diderot, Sorbonne Paris Cité 75205 Paris France.
Chang-Zhi DongInterfaces, Traitements, Organisation et Dynamique des Systemes (ITODYS) UMR 7086 CNRS Université Paris Diderot, Sorbonne Paris Cité 75205 Paris France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to develop original water soluble antagonists of X-linked inhibitor of apoptosis protein (XIAP), a novel bicyclic scaffold was designed based on 8,5-fused bicyclic lactam. During its preparation, a spontaneous rearrangement from 8,5- to 7,5-fused bicyclic lactam was observed and confirmed by MS and NMR analyses, in particular the HMBC spectra. DFT calculations were performed to understand the corresponding mechanism. It was finally prevented through changing the reaction order in the synthesis route and a Smac mimetic with this core structure,

Indexed as

anticancer drugslactamsSmac mimeticsspontaneous rearrangementXIAP antagonists

Identifiers

PMID30652062
PMCPMC6331714

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.