Evidence map›Paper›PMID 30652022›Full record

ArticleFuture science OA2019

Switching of biological therapies in Brazilian patients with rheumatoid arthritis.

Juliana Miranda de Lucena Valim, Fernanda Gomes Gonçalves Chaer, Fernanda D'Oliveira Guimarães da Silveira, Verônica Palmiro da Silva E Lima, Branca Dias Batista de Souza

Open access · goldAbstract read
In one paragraph

Article in Future science OA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Juliana Miranda de Lucena ValimMédica assistente da Reumatologia da ISCMSP, Medicine Department/Rheumatology Division, Santa Casa de Misericórdia de São Paulo, São Paulo-SP/CEP 01221-900, Brazil.
Fernanda Gomes Gonçalves ChaerMédica assistente da Reumatologia da ISCMSP, Medicine Department/Rheumatology Division, Santa Casa de Misericórdia de São Paulo, São Paulo-SP/CEP 01221-900, Brazil.
Fernanda D'Oliveira Guimarães da SilveiraMédica residente da Reumatologia da ISCMSP, Medicine Department/Rheumatology Division, Santa Casa de Misericórdia de São Paulo, São Paulo-SP/CEP 01221-900, Brazil.
Verônica Palmiro da Silva E LimaMédica residente da Reumatologia da ISCMSP, Medicine Department/Rheumatology Division, Santa Casa de Misericórdia de São Paulo, São Paulo-SP/CEP 01221-900, Brazil.
Branca Dias Batista de SouzaMédica assistente da Reumatologia da ISCMSP, Medicine Department/Rheumatology Division, Santa Casa de Misericórdia de São Paulo, São Paulo-SP/CEP 01221-900, Brazil.
Irmandade da Santa Casa de Misericórdia de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo assess drug switching, rates of remission and disease activity in Brazilian patients with rheumatoid arthritis (RA) treated with biologic agents. MATERIALS &

methodsUsing a retrospective method, a total of 94 adult patients were included.

resultsAnti-TNF was the first choice therapy in 85 (90.4%) patients. After an average of 8 years of follow-up, 55 (59%) patients were taking anti-TNF, 18 (19%) abatacept, eight (9%) tocilizumab and 13 (14%) rituximab. In this period, 99 switches of biological therapy were registered in 55 patients.

conclusionAfter 8 years of follow-up, 54% of the RA patients on biological therapy were still experiencing high or moderate activity despite established treatment, including switching between different biologic agents.

Indexed as

anti-TNFbiologicsdiscontinuationdisease activityremission ratesrheumatoid arthritisswitching

Identifiers

PMID30652022
PMCPMC6331703
OpenAlexW2902184252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.