ArticleAntimicrobial resistance and infection control2019
Infection-prevention and control interventions to reduce colonisation and infection of intensive care unit-acquired carbapenem-resistant
Article in Antimicrobial resistance and infection control, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- A comprehensive evaluation of risk factors for mortality, infection and colonization associated with CRGNB in adult solid organ transplant recipients: a systematic review and meta-analysis.Annals of medicine · 2024Pooled it
- Emerging Klebsiella pneumoniae co-harboring carbapenemase genes and hypervirulence determinants in Iran: a molecular and phenotypic investigation.Molecular biology reports · 2026Article
- Global Epidemiology and Antimicrobial Resistance of Klebsiella Pneumoniae Carbapenemase (KPC)-Producing Gram-Negative Clinical Isolates: A Review.Microorganisms · 2025Review
- Risk factors associated with community colonization of extended-spectrum cephalosporin-resistant Enterobacterales from an antibiotic resistance in communities and hospitals (ARCH) study, Guatemala.Scientific reports · 2025Article
- Infection control interventions against carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae in an Iranian referral university hospital: A quasi-experimental study.Antimicrobial resistance and infection control · 2025Article
- Exploring current hypervirulentFrontiers in microbiology · 2025Review
- A Decade-Long Review of the Virulence, Resistance, and Epidemiological Risks ofMicroorganisms · 2024Review
- Epidemiology and outcomes of carbapenem-resistantFrontiers in microbiology · 2024Article
- The ICU-CARB score: a novel clinical scoring system to predict carbapenem-resistant gram-negative bacteria carriage in critically ill patients upon ICU admission.Antimicrobial resistance and infection control · 2023Article
- Efficacy of Active Rapid Molecular Screening and IPC Interventions on Carbapenem-ResistantInfection and drug resistance · 2023Article
- Drug Resistance Genes and Molecular Epidemiological Characteristics of Carbapenem-ResistantInfection and drug resistance · 2023Article
- Antimicrobial stewardship and infection prevention interventions targeting healthcare-associatedBMJ open · 2021Article
- Strategies to Improve Antimicrobial Utilization with a Special Focus on Developing Countries.Life (Basel, Switzerland) · 2021Review
- Carbapenem-ResistantInfection and drug resistance · 2021Article
- Phenotypic Detection of Carbapenem-Resistant Gram-Negative Bacilli from a Clinical Specimen in Sidama, Ethiopia: A Cross-Sectional Study.Infection and drug resistance · 2021Article
- Validation and Extrapolation of a Multimodal Infection Prevention and Control Intervention on Carbapenem-ResistantFrontiers in medicine · 2021Article
- Failure mode and effects analysis on the control effect of multi-drug-resistant bacteria in ICU patients.American journal of translational research · 2021Article
- Impact of multicenter unified enhanced environmental cleaning and disinfection measures on nosocomial infections among patients in intensive care units.The Journal of international medical research · 2020Article
- Risk Factors for Carbapenem-ResistantInfection and drug resistance · 2020Article
- Reducing dissemination of carbapenem-resistantAnnals of translational medicine · 2019Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To determine whether infection-prevention and control (IPC) interventions can reduce the colonisation and infection of intensive care unit (ICU)-acquired carbapenem-resistant Methods: We used a quasi-experimental before-and-after study design. The study was conducted in 4 stages: baseline period, January 2013-June 2013; IPC interventions period including de-escalation and targeted bundle interventions, July 2013-June 2014; modified IPC interventions period, July 2014-June 2015; and follow-up period, July 2015-June 2016. We used modified de-escalation interventions according to patient-risk assessments to prevent the transmission of CRKP. Results: A total of 629 patients were enrolled in study. The incidence of ICU-acquired CRKP colonisation/infection was 10.08 (4.43-16.43) per 1000 ICU patient-days during the baseline period, and significantly decreased early during the IPC interventions, but the colonisation/infections reappeared in April 2014. During the modified IPC intervention and follow-up periods, the incidence of ICU-acquired CRKP colonisations/infections reduced to 5.62 (0.69-6.34) and 2.84 (2.80-2.89), respectively, with ongoing admission of cases with previously acquired CRKP. The incidence of ICU-acquired CRKP catheter-related bloodstream infections decreased from 2.54 during the baseline period to 0.41 during the follow-up period. The incidence of ventilator-associated pneumonia and skin and soft tissue infections showed a downward trend from 2.84 to 0.41 and from 3.4 to 0.47, respectively, with slight fluctuations. Conclusions: Comprehensive IPC interventions including de-escalation and targeted bundle interventions showed a significant reduction in ICU-acquired CRKP colonisations/infections, despite ongoing admission of patients colonised/infected with CRKP.
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