ArticleExperimental and therapeutic medicine2019
Abnormalities of diffusional kurtosis imaging and regional homogeneity in idiopathic generalized epilepsy with generalized tonic-clonic seizures.
Article in Experimental and therapeutic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Deep Learning-Based Pediatric Brain Region Segmentation and Volumetric Analysis for General Growth Pattern in Healthy Children.Journal of imaging informatics in medicine · 2025Article
- A generalized epilepsy network derived from brain abnormalities and deep brain stimulation.Nature communications · 2025Article
- Abnormalities of regional brain activity and executive function in patients with temporal lobe epilepsy: A cross-sectional and longitudinal resting-state functional MRI study.Neuroradiology · 2024Article
- White Matter Function and Network Abnormalities in Patients with Diabetic Retinopathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- The role of the primary sensorimotor system in generalized epilepsy: Evidence from the cerebello-cerebral functional integration.Human brain mapping · 2024Article
- Multi-spectral diffusion MRI mega-analysis in genetic generalized epilepsy: Relation to outcomes.NeuroImage. Clinical · 2023Article
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Abstract
Neuroimaging techniques have been used to investigate idiopathic generalized epilepsy with generalized tonic-clonic seizures (IGE-GTCS) and different studies employing these methods have produced varying results. However, there have been few studies exploring diffusional kurtosis imaging (DKI) and regional homogeneity (ReHo) techniques in patients with IGE-GTCS. In the current study, resting-state functional magnetic resonance imaging (fMRI) and DKI data were collected from 28 patients with IGE-GTCS and 28 healthy controls. The ReHo method and tract-based spatial statistical (TBSS) analysis were performed to compare differences between the groups. Compared with healthy controls, patients with IGE-GTCS exhibited markedly increased ReHo in the bilateral putamen, the thalamus, right pallidum, right supplementary motor area and the bilateral paracentral lobules. Compared with healthy controls, patients with IGE-GTCS also exhibited markedly decreased ReHo in the posterior cingulate/precuneus, left angular gyrus and dorsolateral prefrontal cortex. In patients with IGE-GTCS, DKI revealed lower fractional anisotropy in the left anterior/superior corona radiata, left superior longitudinal fasciculus and genu/body of the corpus callosum. Higher mean diffusivity was detected in the bilateral anterior corona radiata, left superior corona radiata, left cingulum, and genu/body/splenium of the corpus callosum. Furthermore, reduced mean kurtosis values were identified over the bilateral superior/posterior corona radiate, left anterior corona radiata, right superior longitudinal fasciculus, left posterior thalamic radiation and the genu/body/splenium of the corpus callosum. Therefore, the results of the current study revealed abnormalities in spontaneous activity in the gray and white matter tracts in patients with IGE-GTCS. These results suggest that novel MRI technology may be useful to help determine the pathogenesis of IGE-GTCS.
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