ArticleNutrition & metabolism2019
Retinol binding protein 4 and risk of type 2 diabetes in Singapore Chinese men and women: a nested case-control study.
Article in Nutrition & metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Association of baseline and longitudinal plasma retinol-binding protein 4 with all-cause mortality in maintenance hemodialysis patients.Frontiers in endocrinology · 2025Article
- Retinol binding protein 4 and type 2 diabetes: from insulin resistance to pancreatic β-cell function.Endocrine · 2024Review
- The role of novel adipokines in hepatocellular carcinoma progression: a mini review.American journal of cancer research · 2024Review
- Retinol and Retinol Binding Protein 4 Levels and Cardiometabolic Disease Risk.Circulation research · 2022Article
- Interplay between Fatty Acid Binding Protein 4, Fetuin-A, Retinol Binding Protein 4 and Thyroid Function in Metabolic Dysregulation.Metabolites · 2022Review
- Sexual Dimorphism in the Association of Serum Retinol-Binding Protein-4 With Long-Term Dynamic Metabolic Profiles in Non-Diabetes.Frontiers in endocrinology · 2022Article
- Effect of Add-On Therapy of Sodium-Glucose Cotransporter 2 Inhibitors and Dipeptidyl Peptidase 4 Inhibitors on Adipokines in Type 2 Diabetes Mellitus.Journal of clinical medicine research · 2021Article
- Augmentation of RBP4/STRA6 signaling leads to insulin resistance and inflammation and the plausible therapeutic role of vildagliptin and metformin.Molecular biology reports · 2021Article
- Serum biomarker panel for the diagnosis of rheumatoid arthritis.Arthritis research & therapy · 2021Article
- Impact of Gastric Sleeve Surgery on Plasma Retinol Binding Protein 4 and Adipsin Levels in Healthy Male Population.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundAlthough retinol binding protein 4 (RBP4) has been implicated in insulin resistance in experimental studies, the association between RBP4 and risk of type 2 diabetes remains unclear. We assessed this association in a Chinese population, and pooled our results with those from two prior studies.
methodsPlasma RBP4 levels were measured among 571 incident type 2 diabetes cases and 571 controls nested within the Singapore Chinese Health Study. All participants were free of diabetes, cancer and cardiovascular disease at blood collection (1999-2004). Incident cases of physician-diagnosed diabetes were self-reported at subsequent interviews (2006-2010).
resultsPlasma RBP4 levels were significantly higher in men than women, and the respective median values were 30 (interquartile range: 24-35) μg/mL and 25 (interquartile range: 21-31) μg/mL, respectively. With adjustment for diabetes risk factors, compared to the lowest quartile, the odds ratio (OR) and confidence interval (CI) for risk of type 2 diabetes associated with the highest quartile of RBP4 levels were 1.23 (0.73-2.07;
conclusionsIncreased plasma RBP4 levels were associated with higher risk of type 2 diabetes in women but not in men.
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