ArticleHeredity2019
Enhancing genetic disease control by selecting for lower host infectivity and susceptibility.
Article in Heredity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Impact of genomic selection for disease resistance on the spread of infection in a simulated aquaculture population.Genetics, selection, evolution : GSE · 2026Article
- Understanding the direct and indirect impacts of disease response phenotypes on chicken coccidiosis epidemiology: A modelling approach.PloS one · 2026Article
- Spatial scale break in ecological strategies for host use by plant viruses.Frontiers in microbiology · 2026Article
- SIRE 2.0: a novel method for estimating polygenic host effects underlying infectious disease transmission, and analytical expressions for prediction accuracies.Genetics, selection, evolution : GSE · 2025Article
- Performance Comparison of Genomic Best Linear Unbiased Prediction and Four Machine Learning Models for Estimating Genomic Breeding Values in Working Dogs.Animals : an open access journal from MDPI · 2025Article
- Disease resistance and infectivity of virus susceptible and resistant common carp strains.Scientific reports · 2024Article
- Selective breeding can contribute to bovine tuberculosis control and eradication.Irish veterinary journal · 2023Review
- Applying genetic technologies to combat infectious diseases in aquaculture.Reviews in aquaculture · 2023Review
- Identification of intestinal and fecal microbial biomarkers using a porcine social stress model.Frontiers in microbiology · 2023Article
- Optimal experimental designs for estimating genetic and non-genetic effects underlying infectious disease transmission.Genetics, selection, evolution : GSE · 2022Article
- Tomato genomic prediction for good performance under high-temperature and identification of loci involved in thermotolerance response.Horticulture research · 2021Article
- Systematic Review of the Interaction between Nutrition and Immunity in Livestock: Effect of Dietary Supplementation with Synthetic Amino Acids.Animals : an open access journal from MDPI · 2021Review
- Why genetic selection to reduce the prevalence of infectious diseases is way more promising than currently believed.Genetics · 2021Article
- Characterization of potential superspreader farms for bovine tuberculosis: A review.Veterinary medicine and science · 2021Review
- Estimating individuals' genetic and non-genetic effects underlying infectious disease transmission from temporal epidemic data.PLoS computational biology · 2020Article
- The economic value of RGenetics, selection, evolution : GSE · 2020Article
- In vivo model to study the impact of genetic variation on clinical outcome of mastitis in uniparous dairy cows.BMC veterinary research · 2020Article
- Genetic differences in host infectivity affect disease spread and survival in epidemics.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Infectious diseases have a huge impact on animal health, production and welfare, and human health. Understanding the role of host genetics in disease spread is important for developing disease control strategies that efficiently reduce infection incidence and risk of epidemics. While heritable variation in disease susceptibility has been targeted in livestock breeding, emerging evidence suggests that there is additional genetic variation in host infectivity, but the potential benefits of including infectivity into selection schemes are currently unknown. A Susceptible-Infected-Recovered epidemiological model incorporating polygenic genetic variation in both susceptibility and infectivity was combined with quantitative genetics selection theory to assess the non-linear impact of genetic selection on field measures of epidemic risk and severity. Response to 20 generations of selection was calculated in large simulated populations, exploring schemes differing in accuracy and intensity. Assuming moderate genetic variation in both traits, 50% selection on susceptibility required seven generations to reduce the basic reproductive number R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.