ArticleNature communications2019
A diversity-oriented rhodamine library for wide-spectrum bactericidal agents with low inducible resistance against resistant pathogens.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 65 citations in OpenAlex.
- General (hetero)polyaryl amine synthesis via multicomponent cycloaromatization of amines.Nature communications · 2025Article
- Computational prediction of CNP0387675 as a non-nucleoside inhibitor of MraY, from natural product-based multi-template screening againstFrontiers in microbiology · 2025Article
- Rhodamine 19 Alkyl Esters as Effective Antibacterial Agents.International journal of molecular sciences · 2024Article
- Synthesis and antibacterial activity of 2-benzylidene-3-oxobutanamide derivatives against resistant pathogens.RSC medicinal chemistry · 2023Article
- Multicolor ultralong phosphorescence from perovskite-like octahedral α-AlFNature communications · 2022Article
- Machine Learning Study of Metabolic NetworksMolecular pharmaceutics · 2022Article
- Functionalization of Rhodamine Platforms with 3-Hydroxy-4-pyridinone Chelating Units and Its Fluorescence Behavior towards Fe(III).Molecules (Basel, Switzerland) · 2022Article
- A Sustainable and Antimicrobial Food Packaging Film for Potential Application in Fresh Produce Packaging.Frontiers in nutrition · 2022Article
- Modular Synthetic Approach to Silicon-Rhodamine Homologues and Analogues via Bis-aryllanthanum Reagents.Organic letters · 2021Article
- Recent Progress in Small Spirocyclic, Xanthene-Based Fluorescent Probes.Molecules (Basel, Switzerland) · 2020Review
- Recent advances in construction of small molecule-based fluorophore-drug conjugates.Journal of pharmaceutical analysis · 2020Review
- Real-time detection of single-molecule reaction by plasmon-enhanced spectroscopy.Science advances · 2020Article
- Zinc-doped Prussian blue enhances photothermal clearance of Staphylococcus aureus and promotes tissue repair in infected wounds.Nature communications · 2019Article
- Dual Metal-Organic Framework Heterointerface.ACS central science · 2019Article
Corrections and comments
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Authors and funding
20 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial resistance is a public health emergency and warrants coordinated global efforts. Challenge is that no alternative molecular platform has been identified for discovery of abundant antimicrobial hit compounds. Xanthene libraries have been screened for bioactive compounds. However, the potentially accessible chemistry space of xanthene dyes is limited by the existing xanthene synthesis. Herein we report a mild one-step synthesis, which permits late-stage introduction of a xanthene moiety onto i.e. natural products, pharmaceuticals, and bioactive compounds and construction of a focused library of rhodamine dyes exhibiting facile functional, topographical and stereochemical diversity. In vitro screening yields 37 analogs with mid-to-high bactericidal activity against WHO priority drug-resistant pathogens. These findings suggest that synthetic dye libraries exhibiting high structural diversity is a feasible chemical space combating antibacterial resistance, to complement the natural sources.
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