ArticleNature communications2019
Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
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- Application of a uniaxial force by pulling the skin around the mammary gland may affect the orientation of the ducts and the length of the mammary ductal network: Findings from computational modeling and laboratory experiments.PLoS computational biology · 2026Article
- Developmentally inspired synthetic kidney engineering.Nature biotechnology · 2026Review
- Review
- Morphogen gradients are regulated by porous media characteristics of the developing tissue.Development (Cambridge, England) · 2025Article
- Morphogenic, molecular and cellular adaptations for unidirectional airflow in the chicken lung.Development (Cambridge, England) · 2025Article
- The Mechanics of Building Functional Organs.Cold Spring Harbor perspectives in biology · 2025Review
- The dynamics of tubulogenesis in development and disease.Development (Cambridge, England) · 2025Review
- Mathematical modeling reveals cell differentiation processes and progenitor kinetics necessary for proper nephrogenesis.Frontiers in cell and developmental biology · 2025Article
- Wnt/β-Catenin Signaling and Congenital Abnormalities of Kidney and Urinary Tract.Kidney diseases (Basel, Switzerland) · 2024Review
- Creatine Kinase-MM/Proto-oncogene Tyrosine-Protein Kinase Receptor as a Sensitive Indicator for Duchenne Muscular Dystrophy Carriers.Molecular neurobiology · 2024Article
- Mechanical state transitions in the regulation of tissue form and function.Nature reviews. Molecular cell biology · 2024Review
- Phenotypic characterization of liver tissue heterogeneity through a next-generation 3D single-cell atlas.Scientific reports · 2024Article
- The developing murine kidney actively negotiates geometric packing conflicts to avoid defects.Developmental cell · 2023Article
- Systems for intricate patterning of the vertebrate anatomy.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Article
- Theory of branching morphogenesis by local interactions and global guidance.Nature communications · 2021Article
- Non-thermal atmospheric pressure plasma activates Wnt/β-catenin signaling in dermal papilla cells.Scientific reports · 2021Article
- From embryos to embryoids: How external signals and self-organization drive embryonic development.Stem cell reports · 2021Review
- The biomechanical basis of biased epithelial tube elongation in lung and kidney development.Development (Cambridge, England) · 2021Article
- Roadmap for the multiscale coupling of biochemical and mechanical signals during development.Physical biology · 2021Review
Corrections and comments
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6 authors.
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Abstract
Branching patterns and regulatory networks differ between branched organs. It has remained unclear whether a common regulatory mechanism exists and how organ-specific patterns can emerge. Of all previously proposed signalling-based mechanisms, only a ligand-receptor-based Turing mechanism based on FGF10 and SHH quantitatively recapitulates the lung branching patterns. We now show that a GDNF-dependent ligand-receptor-based Turing mechanism quantitatively recapitulates branching of cultured wildtype and mutant ureteric buds, and achieves similar branching patterns when directing domain outgrowth in silico. We further predict and confirm experimentally that the kidney-specific positive feedback between WNT11 and GDNF permits the dense packing of ureteric tips. We conclude that the ligand-receptor based Turing mechanism presents a common regulatory mechanism for lungs and kidneys, despite the differences in the molecular implementation. Given its flexibility and robustness, we expect that the ligand-receptor-based Turing mechanism constitutes a likely general mechanism to guide branching morphogenesis and other symmetry breaks during organogenesis.
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