ArticleNature communications2019
Early preclinical detection of prions in the skin of prion-infected animals.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 48 papers.
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48citing papers in PubMed
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Who cites it
48 citing papers in PubMed.
- From a prion seed to a tree of discoveries: Byron Caughey's RT-QuIC legacy in protein misfolding research.Acta neuropathologica · 2026Review
- Molecular signatures and biomarker development for limbic-predominant age-related TDP-43 encephalopathy (LATE).Acta neuropathologica · 2026Review
- Age-dependent peripheral dissemination of α-synuclein seeds: mechanistic basis for blood-based early detection of Parkinson's disease.Acta neuropathologica communications · 2026Article
- Identification of an altered gut microbiome and the protective effect of microbiome changer in prion diseases.Veterinary research · 2026Article
- Prions and protein aggregates as pathogens, self-propagating structures, biomarkers, and therapeutic targets.Microbiology and molecular biology reviews : MMBR · 2025Review
- White-Tailed Deer Prion Protein Gene Variability Suggests Selection Against Chronic Wasting Disease in Canada's Prairies.Viruses · 2025Article
- Tracking Prions by RT-QuIC: An Update.Sub-cellular biochemistry · 2025Review
- Prion Disease Diagnostic Biomarker Utility in Pre-symptomatic Disease.Sub-cellular biochemistry · 2025Review
- Chaperones as Potential Pharmacological Targets for Treating Protein Aggregation Illness.Current protein & peptide science · 2025Review
- Multisite Skin Biopsies vs Cerebrospinal Fluid for Prion Seeding Activity in the Diagnosis of Prion Diseases.JAMA neurology · 2024Article
- Seeding activity of skin misfolded tau as a biomarker for tauopathies.Molecular neurodegeneration · 2024Article
- α-Synuclein seed amplification technology for Parkinson's disease and related synucleinopathies.Trends in biotechnology · 2024Review
- Detection of prions in matching post-mortem skin and cerebrospinal fluid samples using second-generation real-time quaking-induced conversion assay.Scientific reports · 2024Article
- Large-scale validation of skin prion seeding activity as a biomarker for diagnosis of prion diseases.Acta neuropathologica · 2024Article
- Conventional and State-of-the-Art Detection Methods of Bovine Spongiform Encephalopathy (BSE).International journal of molecular sciences · 2023Review
- Differential diagnosis of mild cognitive impairment of Alzheimer's disease by Simoa p-tau181 measurements with matching plasma and CSF.Frontiers in molecular neuroscience · 2023Article
- Hexameric Aggregation Nucleation Core Sequences and Diversity of Pathogenic Tau Strains.Pathogens (Basel, Switzerland) · 2022Article
- Site-Specific Phospho-Tau Aggregation-Based Biomarker Discovery for AD Diagnosis and Differentiation.ACS chemical neuroscience · 2022Article
- Catechol-containing compounds are a broad class of protein aggregation inhibitors: Redox state is a key determinant of the inhibitory activities.Pharmacological research · 2022Article
- Establishment of a Special Platform for the Research of Prion and the Diagnosis of Human Prion Disease - China's Studies.China CDC weekly · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
25 authors.
Zerui WangDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, 44106, OH, USA.
Matteo MancaLaboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, 59840, MT, USA.
Aaron FoutzNational Prion Disease Pathology Surveillance Center, Case Western Reserve University School of Medicine, Cleveland, 44106, OH, USA.
Manuel V CamachoDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, 44106, OH, USA.
Gregory J RaymondLaboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, 59840, MT, USA.
Brent RaceLaboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, 59840, MT, USA.
Christina D OrruLaboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, 59840, MT, USA.
Jue YuanDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, 44106, OH, USA.
Pingping ShenDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, 44106, OH, USA.
Baiya LiDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, 44106, OH, USA.
Yue LangDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, 44106, OH, USA.
Johnny DangDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, 44106, OH, USA.
Alise AdornatoDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, 44106, OH, USA.
Katie WilliamsLaboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, 59840, MT, USA.
Nicholas R MaurerDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, 44106, OH, USA.
Pierluigi GambettiDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, 44106, OH, USA.
Bin XuDepartment of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, 24061, Virginia, USA.
Witold SurewiczDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, 44106, OH, USA.
Robert B PetersenDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, 44106, OH, USA.
Xiaoping DongState Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, The People's Republic of China.
Brian S ApplebyDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, 44106, OH, USA.
Byron CaugheyLaboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, 59840, MT, USA. bcaughey@nih.gov.ORCID http://orcid.org/0000-0002-3928-6101
Li CuiDepartment of Neurology, The First Hospital of Jilin University, Changchun, 130021, Jilin Province, The People's Republic of China. chuili1967@126.com.
Qingzhong KongDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, 44106, OH, USA. qxk2@case.edu.
Wen-Quan ZouDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, 44106, OH, USA. wxz6@case.edu.
Funding
Detection of PrionsZIAAI001086 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CAUGHEY, BYRON · 2009 to 2025
$18.1MRole of skin prions in disease transmission and diagnostic testing of human prion diseaseR01NS109532 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KONG, QINGZHONG · 2018 to 2022
$2.9MPathogenicity of prion protein aggregates from uninfected cells and brainsR01NS062787 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI ZOU, WEN-QUAN · 2009 to 2013
$1.4MCervid to human prion transmissionR01NS088604 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI KONG, QINGZHONG · 2015 to 2018
$1.4MGenerating iPSC-derived Neurons to Explore Formation & Inhibition of Human PrionsR21NS087588 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI QI, XIN, TESAR, PAUL JOSEPH · 2014 to 2015
$436kNIH HHS NS062787NIH HHS NS087588NIH HHS NS088604NIH HHS NS109532NINDS NIH HHS R01 NS062787NINDS NIH HHS R01 NS088604NINDS NIH HHS R01 NS109532NINDS NIH HHS R21 NS087588
Abstract
A definitive pre-mortem diagnosis of prion disease depends on brain biopsy for prion detection currently and no validated alternative preclinical diagnostic tests have been reported to date. To determine the feasibility of using skin for preclinical diagnosis, here we report ultrasensitive serial protein misfolding cyclic amplification (sPMCA) and real-time quaking-induced conversion (RT-QuIC) assays of skin samples from hamsters and humanized transgenic mice (Tg40h) at different time points after intracerebral inoculation with 263K and sCJDMM1 prions, respectively. sPMCA detects skin PrP
Indexed as
AnimalsAntibodies, MonoclonalBiological AssayBiomarkersBrainDisease Models, AnimalFeasibility StudiesFemaleHumansMesocricetusMiceMice, TransgenicPrPSc ProteinsScrapieSkinAntibodies, MonoclonalBiomarkersPrPSc Proteins
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