Evidence map›Paper›PMID 30651382›Full record

ArticleNeurology2019

Impaired olfaction is associated with cognitive decline and neurodegeneration in the brain.

Christina S Dintica, Anna Marseglia, Debora Rizzuto, Rui Wang, Janina Seubert, Konstantinos Arfanakis, David A Bennett, Weili Xu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 4 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 4 syntheses or guidelines pooled it, 225 citations in OpenAlex.

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  13. Olfactory decline tracks central-to-peripheral spread of tau pathology in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 3 countries.

Christina S DinticaFrom the Aging Research Center (C.S.D., A.M., D.R., R.W., J.S., W.X.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; Department of Clinical Neuroscience (J.S.), Psychology Division, Karolinska Institutet, Stockholm, Sweden; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology, Chicago; Rush Alzheimer's Disease Center (K.A., D.A.B.), and Department of Neurological Sciences (D.A.B.), Rush University Medical Center, Chicago, IL; and Department of Epidemiology and Biostatistics (W.X.), School of Public Health, Tianjin Medical University, China. christina.dintica@ki.se xuweili@tmu.edu.cn.ORCID 0000-0001-8186-8140
Anna MarsegliaFrom the Aging Research Center (C.S.D., A.M., D.R., R.W., J.S., W.X.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; Department of Clinical Neuroscience (J.S.), Psychology Division, Karolinska Institutet, Stockholm, Sweden; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology, Chicago; Rush Alzheimer's Disease Center (K.A., D.A.B.), and Department of Neurological Sciences (D.A.B.), Rush University Medical Center, Chicago, IL; and Department of Epidemiology and Biostatistics (W.X.), School of Public Health, Tianjin Medical University, China.
Debora RizzutoFrom the Aging Research Center (C.S.D., A.M., D.R., R.W., J.S., W.X.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; Department of Clinical Neuroscience (J.S.), Psychology Division, Karolinska Institutet, Stockholm, Sweden; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology, Chicago; Rush Alzheimer's Disease Center (K.A., D.A.B.), and Department of Neurological Sciences (D.A.B.), Rush University Medical Center, Chicago, IL; and Department of Epidemiology and Biostatistics (W.X.), School of Public Health, Tianjin Medical University, China.
Rui WangFrom the Aging Research Center (C.S.D., A.M., D.R., R.W., J.S., W.X.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; Department of Clinical Neuroscience (J.S.), Psychology Division, Karolinska Institutet, Stockholm, Sweden; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology, Chicago; Rush Alzheimer's Disease Center (K.A., D.A.B.), and Department of Neurological Sciences (D.A.B.), Rush University Medical Center, Chicago, IL; and Department of Epidemiology and Biostatistics (W.X.), School of Public Health, Tianjin Medical University, China.
Janina SeubertFrom the Aging Research Center (C.S.D., A.M., D.R., R.W., J.S., W.X.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; Department of Clinical Neuroscience (J.S.), Psychology Division, Karolinska Institutet, Stockholm, Sweden; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology, Chicago; Rush Alzheimer's Disease Center (K.A., D.A.B.), and Department of Neurological Sciences (D.A.B.), Rush University Medical Center, Chicago, IL; and Department of Epidemiology and Biostatistics (W.X.), School of Public Health, Tianjin Medical University, China.
Konstantinos ArfanakisFrom the Aging Research Center (C.S.D., A.M., D.R., R.W., J.S., W.X.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; Department of Clinical Neuroscience (J.S.), Psychology Division, Karolinska Institutet, Stockholm, Sweden; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology, Chicago; Rush Alzheimer's Disease Center (K.A., D.A.B.), and Department of Neurological Sciences (D.A.B.), Rush University Medical Center, Chicago, IL; and Department of Epidemiology and Biostatistics (W.X.), School of Public Health, Tianjin Medical University, China.
David A BennettFrom the Aging Research Center (C.S.D., A.M., D.R., R.W., J.S., W.X.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; Department of Clinical Neuroscience (J.S.), Psychology Division, Karolinska Institutet, Stockholm, Sweden; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology, Chicago; Rush Alzheimer's Disease Center (K.A., D.A.B.), and Department of Neurological Sciences (D.A.B.), Rush University Medical Center, Chicago, IL; and Department of Epidemiology and Biostatistics (W.X.), School of Public Health, Tianjin Medical University, China.
Weili XuFrom the Aging Research Center (C.S.D., A.M., D.R., R.W., J.S., W.X.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; Department of Clinical Neuroscience (J.S.), Psychology Division, Karolinska Institutet, Stockholm, Sweden; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology, Chicago; Rush Alzheimer's Disease Center (K.A., D.A.B.), and Department of Neurological Sciences (D.A.B.), Rush University Medical Center, Chicago, IL; and Department of Epidemiology and Biostatistics (W.X.), School of Public Health, Tianjin Medical University, China. christina.dintica@ki.se xuweili@tmu.edu.cn.
Rush University Medical Center · US

Funding

SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Multimodal MRI biomarkers of small vessel disease for older persons with and without dementia.UH3NS100599 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI ARFANAKIS, KONSTANTINOS, SCHNEIDER, JULIE A. · 2018 to 2020
$3.5M
6 · The paper itself

Abstract

objectiveWe aimed to examine whether impaired olfaction is associated with cognitive decline and indicators of neurodegeneration in the brain of dementia-free older adults.

methodsWithin the Rush Memory and Aging Project, 380 dementia-free participants (mean age = 78 years) were followed for up to 15 years, and underwent MRI scans. Olfactory function was assessed using the Brief Smell Identification Test (B-SIT) at baseline, and categorized as anosmia (B-SIT <6), hyposmia (B-SIT 6-10 in men and 6-10.25 in women), and normal (B-SIT 10.25-12 in men and 10.5-12 in women). Cognitive function was annually assessed with a battery of 21 tests, from which composite scores were derived. Structural total and regional brain volumes were estimated. Data were analyzed using linear regression and mixed-effects models.

resultsAt study entry, 138 (36.3%) had normal olfactory function, 213 (56.1%) had hyposmia, and 29 (7.6%) had anosmia. In multiadjusted mixed-effects models, hyposmia (β = -0.03, 95% confidence interval [CI] -0.05 to -0.02) and anosmia (β = -0.13, 95% CI -0.16 to -0.09) were associated with faster rate of cognitive decline compared to normal olfaction. On MRI, impaired olfaction (hyposmia or anosmia) was related to smaller volumes of the hippocampus (β = -0.19, 95% CI -0.33 to -0.05), and in the entorhinal (β = -0.16, 95% CI -0.24 to -0.08), fusiform (β = -0.45, 95% CI -0.78 to -0.14), and middle temporal (β = -0.38, 95% CI -0.72 to -0.01) cortices.

conclusionImpaired olfaction predicts faster cognitive decline and might indicate neurodegeneration in the brain among dementia-free older adults.

Indexed as

AgedAged, 80 and overBrainCognitive DysfunctionEntorhinal CortexFemaleHippocampusHumansLinear ModelsMagnetic Resonance ImagingMaleNeurodegenerative DiseasesNeuropsychological TestsOlfaction DisordersOrgan SizeTemporal Lobe

Identifiers

PMID30651382
PMCPMC6382360
OpenAlexW2908620907

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.