Evidence map›Paper›PMID 30651368›Full record

ArticleJournal of virology2019

Minichromosome Maintenance Proteins Cooperate with LANA during the G

Prerna Dabral, Timsy Uppal, Cyprian C Rossetto, Subhash C Verma

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. MCM4 acts as a biomarker for LUAD prognosis.Journal of cellular and molecular medicine · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Prerna DabralDepartment of Microbiology and Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Timsy UppalDepartment of Microbiology and Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Cyprian C RossettoDepartment of Microbiology and Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Subhash C VermaDepartment of Microbiology and Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA scverma@medicine.nevada.edu.ORCID 0000-0002-0492-6578
University of Nevada, Reno · US

Funding

KSHV Lytic DNA Replication and its Control MechanismR01AI105000 · NIAID · UNIVERSITY OF NEVADA RENO · PI VERMA, SUBHASH C · 2013 to 2017
$1.8M
KSHV Genome Replication during Primary InfectionR01CA174459 · NCI · UNIVERSITY OF NEVADA RENO · PI VERMA, SUBHASH C · 2013 to 2017
$1.5M
NCI NIH HHS R01 CA174459NIAID NIH HHS R01 AI105000
6 · The paper itself

Abstract

Latency-associated nuclear antigen (LANA) is essential for maintaining the viral genome by regulating replication and segregation of the viral episomes. The virus maintains 50 to 100 episomal copies during latency and replicates in synchrony with the cellular DNA of the infected cells. Since virus lacks its own replication machinery, it utilizes the cellular proteins for replication and maintenance, and LANA has been shown to make many of these proteins available for replication by directly recruiting them to the viral origin of replication within the terminal repeat (TR) region. Our studies identified members of the minichromosome maintenance (MCM) complex as potential LANA-interacting proteins. Here, we show that LANA specifically interacts with the components of the MCM complex, primarily during the G

Indexed as

Antigens, ViralCell DivisionCell LineCell Line, TumorCell NucleusDNA ReplicationDNA, ViralG1 PhaseGenome, ViralHEK293 CellsHerpesvirus 8, HumanHumansMinichromosome Maintenance ProteinsNuclear ProteinsReplication OriginSarcoma, KaposiAntigens, ViralDNA, Virallatency-associated nuclear antigenMinichromosome Maintenance ProteinsNuclear ProteinsKSHVlatencylatent DNA replicationMCMstumor virus

Identifiers

PMID30651368
PMCPMC6430539
OpenAlexW2910103689

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.