Evidence map›Paper›PMID 30651364›Full record

ArticleJournal of virology2019

The Nonstructural NS1 Protein of Influenza Viruses Modulates

Julia Dubois, Aurélien Traversier, Thomas Julien, Blandine Padey, Bruno Lina, Jean-Christophe Bourdon, Virginie Marcel, Guy Boivin, Manuel Rosa-Calatrava, Olivier Terrier

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Proteomic Analysis of Influenza.Advances in experimental medicine and biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Julia DuboisCIRI, Centre International de Recherche en Infectiologie, (Team VirPath ), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.
Aurélien TraversierCIRI, Centre International de Recherche en Infectiologie, (Team VirPath ), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.
Thomas JulienCIRI, Centre International de Recherche en Infectiologie, (Team VirPath ), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.
Blandine PadeyCIRI, Centre International de Recherche en Infectiologie, (Team VirPath ), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.
Bruno LinaCIRI, Centre International de Recherche en Infectiologie, (Team VirPath ), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.
Jean-Christophe BourdonDivision of Cancer Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom.
Virginie MarcelINSERM U1052, CNRS UMR5286, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.
Guy BoivinCentre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Québec and Université Laval, Québec, Canada.
Manuel Rosa-Calatrava *CIRI, Centre International de Recherche en Infectiologie, (Team VirPath ), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.
Olivier Terrier *CIRI, Centre International de Recherche en Infectiologie, (Team VirPath ), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France olivier.terrier@univ-lyon1.fr.ORCID 0000-0001-9393-7684
Université Claude Bernard Lyon 1 · FRCentre hospitalier universitaire de Québec · CAUniversity of Dundee · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza A viruses (IAV) are known to modulate and "hijack" several cellular host mechanisms, including gene splicing and RNA maturation machineries. These modulations alter host cellular responses and enable an optimal expression of viral products throughout infection. The interplay between the host protein p53 and IAV, in particular through the viral nonstructural protein NS1, has been shown to be supportive for IAV replication. However, it remains unknown whether alternatively spliced isoforms of p53, known to modulate p53 transcriptional activity, are affected by IAV infection and contribute to IAV replication. Using a

Indexed as

A549 CellsAlternative SplicingCell Line, TumorHumansImmunity, InnateInfluenza A virusInfluenza, HumanInterferonsmRNA Cleavage and Polyadenylation FactorsTumor Suppressor Protein p53Viral Nonstructural ProteinsVirus ReplicationINS1 protein, influenza virusInterferonsmRNA Cleavage and Polyadenylation FactorsTP53 protein, humanTumor Suppressor Protein p53Viral Nonstructural Proteinsantiviral responseCPSF30influenza virusesp53splicingvirus-host interactions

Identifiers

PMID30651364
PMCPMC6430556
OpenAlexW2910361792

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.