ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Superficial Layers Suppress the Deep Layers to Fine-tune Cortical Coding.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Frequency and laminar profile of feature-specific visual activity revealed by interleaved EEG-fMRI.eLife · 2026Article
- Neuropixels Opto: combining high-resolution electrophysiology and optogenetics.Nature methods · 2026Article
- Alpha-Synuclein in Neurodegeneration: From Shared Biology to Disease-Specific Phenotypes.Cells · 2026Review
- Bilateral integration in somatosensory cortex is controlled by behavioral relevance.Nature neuroscience · 2025Article
- Somatostatin neurons detect stimulus-reward contingencies to reduce neocortical inhibition during learning.Cell reports · 2025Article
- Neocortical somatostatin neuron diversity in cognition and learning.Trends in neurosciences · 2025Review
- Touch-evoked traveling waves establish a translaminar spacetime code.Science advances · 2025Article
- Site-specific seeding of Lewy pathology induces distinct pre-motor cellular and dendritic vulnerabilities in the cortex.Nature communications · 2024Article
- A latent pool of neurons silenced by sensory-evoked inhibition can be recruited to enhance perception.Neuron · 2024Article
- Population encoding of stimulus features along the visual hierarchy.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Effects of optogenetic silencing the anterior cingulate cortex in a delayed non-match to trajectory task.Oxford open neuroscience · 2024Article
- Article
- Population encoding of stimulus features along the visual hierarchy.bioRxiv : the preprint server for biology · 2023Article
- Optogenetic stimulation shapes dendritic trees of infragranular cortical pyramidal cells.Frontiers in cellular neuroscience · 2023Article
- Distinct local and brain-wide networks are activated by optogenetic stimulation of neurons specific to each layer of motor cortex.NeuroImage · 2022Article
- Translaminar recurrence from layer 5 suppresses superficial cortical layers.Nature communications · 2022Article
- A deep-learning approach for online cell identification and trace extraction in functional two-photon calcium imaging.Nature communications · 2022Article
- Layer-specific activation in human primary somatosensory cortex during tactile temporal prediction error processing.NeuroImage · 2022Article
- Thalamocortical Mechanisms Regulating the Relationship between Transient Beta Events and Human Tactile Perception.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Multiple Mechanistically Distinct Timescales of Neocortical Plasticity Occur During Habituation.Frontiers in cellular neuroscience · 2022Article
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4 authors.
Funding
Abstract
The descending microcircuit from layer 2/3 (L2/3) to layer 5 (L5) is one of the strongest excitatory pathways in the cortex, presumably forming a core component of its feedforward hierarchy. To date, however, no experiments have selectively tested the impact of L2/3 activity on L5 during active sensation. We used optogenetic, cell-type-specific manipulation of L2/3 neurons in the barrel cortex of actively sensing mice (of either sex) to elucidate the significance of this pathway to sensory coding in L5. Contrary to standard models, activating L2/3 predominantly suppressed spontaneous activity in L5, whereas deactivating L2/3 mainly facilitated touch responses in L5. Somatostatin interneurons are likely important to this suppression because their optogenetic deactivation significantly altered the functional impact of L2/3 onto L5. The net effect of L2/3 was to enhance the stimulus selectivity and expand the range of L5 output. These data imply that the core cortical pathway increases the selectivity and expands the range of cortical output through feedforward inhibition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.