Evidence map›Paper›PMID 30651296›Full record

ArticleDevelopment (Cambridge, England)2019

Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling.

Thomas Volckaert, Tingting Yuan, Jie Yuan, Eistine Boateng, Seantel Hopkins, Jin-San Zhang, Victor J Thannickal, Reinhard Fässler, Stijn P De Langhe

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Thomas VolckaertDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA.
Tingting YuanDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA.
Jie YuanDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA.
Eistine BoatengDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA.
Seantel HopkinsDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA.
Jin-San ZhangSchool of Pharmaceutical Sciences and the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Victor J ThannickalDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA.
Reinhard FässlerDepartment of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Stijn P De LangheDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, AL 35294, USA sdelanghe@uabmc.edu.ORCID 0000-0003-3867-4572
University of Alabama at Birmingham · USMax Planck Institute of Biochemistry · DEMayo Clinic · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
HL-Lung stem cells and their niches.R01HL132156 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DE LANGHE, STIJN PIET JOHAN · 2016 to 2019
$2.0M
HL-Role of c-Myc in myofibroblast differentiation in pulmonary fibrosisR01HL126732 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DE LANGHE, STIJN PIET JOHAN, RICHES, DAVID W. · 2015 to 2018
$1.8M
NCI NIH HHS P30 CA013148NHLBI NIH HHS R01 HL126732NHLBI NIH HHS R01 HL132156
6 · The paper itself

Abstract

Organ growth and tissue homeostasis rely on the proliferation and differentiation of progenitor cell populations. In the developing lung, localized

Indexed as

Cell LineageSignal TransductionAdaptor Proteins, Signal TransducingAnimalsbeta CateninCell Cycle ProteinsCell DifferentiationCytoplasmEpithelial CellsFemaleFibroblast Growth Factor 10Hippo Signaling PathwayLungMaleMiceModels, BiologicalAdaptor Proteins, Signal Transducingbeta CateninCell Cycle ProteinsFgf10 protein, mouseFibroblast Growth Factor 10PhosphoproteinsProtein Serine-Threonine KinasesScaffold Protein ILKTrans-ActivatorsWwtr1 protein, mouseYap1 protein, mouseYAP-Signaling ProteinsDifferentiationFgf10Fgfr2HippoIlkIntegrinLungProgenitorYapβ-Catenin

Identifiers

PMID30651296
PMCPMC6361136
OpenAlexW2909480335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.