Evidence map›Paper›PMID 30651286›Full record

ArticleG3 (Bethesda, Md.)2019

Identification of Gene Variants Associated with Melanocyte Stem Cell Differentiation in Mice Predisposed for Hair Graying.

Allison C Fialkowski, Denise J Levy, Dawn E Watkins-Chow, Joseph W Palmer, Roshan Darji, Hemant K Tiwari, William J Pavan, Melissa L Harris

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in G3 (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Gray Hair: From Preventive to Treatment.Clinical, cosmetic and investigational dermatology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Allison C FialkowskiDepartment of Biostatistics.
Denise J LevyUniversity of Alabama at Birmingham, Birmingham, AL, and.
Dawn E Watkins-ChowUniversity of Alabama at Birmingham, Birmingham, AL, and.
Joseph W PalmerGenetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Roshan DarjiGenetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Hemant K TiwariDepartment of Biostatistics.
William J PavanUniversity of Alabama at Birmingham, Birmingham, AL, and.
Melissa L HarrisGenetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD harrisml@uab.edu.ORCID 0000-0001-6223-1611
University of Alabama at Birmingham · USNational Institutes of Health · USNational Human Genome Research Institute · US

Funding

Building an in-vivo gene regulatory network for melanocyte stem cell maintenance.R00AG047128 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HARRIS, MELISSA L · 2016 to 2018
$745k
NIA NIH HHS K99 AG047128NIA NIH HHS R00 AG047128
6 · The paper itself

Abstract

Age-related hair graying is caused by malfunction in the regenerative potential of the adult pigmentation system. The retention of hair color over the life of an organism is dependent on the ability of the melanocyte stem cells and their progeny to produce pigment each time a new hair grows. Age-related hair graying is variable in association with genetic background suggesting that quantitative trait loci influencing this trait can be identified. Identification of these quantitative trait loci may lead to the discovery of novel and interesting genes involved in stem cell biology and/or melanogenesis. With this in mind we developed previously a sensitized, mouse modifier screen and discovered that the DBA/1J background is particularly resistant to melanocyte stem cell differentiation in comparison to the C57BL/6J background. Melanocyte stem cell differentiation generally precedes hair graying and is observed in melanocyte stem cells with age. Using quantitative trait loci analysis, we have now identified three quantitative trait loci on mouse chromosomes 7, 13, and X that are associated with DBA/1J-mediated variability in melanocyte stem cell differentiation. Taking advantage of publicly-available mouse sequence and variant data, in silico protein prediction programs, and whole genome gene expression results we describe a short list of potential candidate genes that we anticipate to be involved in melanocyte stem cell biology in mice.

Indexed as

Cell DifferentiationMelanocytesQuantitative Trait LociAnimalsFemaleGenetic Association StudiesHair ColorMaleMiceMice, Inbred C57BLMice, Inbred DBAStem Cellshair grayingmelanocyte stem cellmodifierQTL

Identifiers

PMID30651286
PMCPMC6404613
OpenAlexW2910366763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.