Evidence map›Paper›PMID 30651275›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2019

Measurement of Tumor Antioxidant Capacity and Prediction of Chemotherapy Resistance in Preclinical Models of Ovarian Cancer by Positron Emission Tomography.

Hannah E Greenwood, Patrick N McCormick, Thibault Gendron, Matthias Glaser, Raul Pereira, Oliver D K Maddocks, Kerstin Sander, Tong Zhang, Norman Koglin, Mark F Lythgoe and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Review
  3. Compact and cGMP-compliant automated synthesis of [EJNMMI radiopharmacy and chemistry · 2025
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  10. Is System xCancers · 2023
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  11. Feasibility of [Tomography (Ann Arbor, Mich.) · 2023
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  15. Radiology · 2022
    Article
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  17. Article
  18. Robust and Facile Automated Radiosynthesis of [Molecular imaging and biology · 2021
    Article
  19. Latest Advances in Imaging Oxidative Stress in Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Hannah E GreenwoodCentre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom.
Patrick N McCormickCentre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom.
Thibault GendronDepartment of Chemistry, Institute of Nuclear Medicine, University College London, London, United Kingdom.
Matthias GlaserDepartment of Chemistry, Institute of Nuclear Medicine, University College London, London, United Kingdom.
Raul PereiraCentre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom.
Oliver D K MaddocksWolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0002-5551-9091
Kerstin SanderDepartment of Chemistry, Institute of Nuclear Medicine, University College London, London, United Kingdom.
Tong ZhangWolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.
Norman KoglinLife Molecular Imaging GmbH, Berlin, Germany.
Mark F LythgoeCentre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom.
Erik ÅrstadDepartment of Chemistry, Institute of Nuclear Medicine, University College London, London, United Kingdom.ORCID 0000-0002-3240-2106
Daniel HochhauserCancer Research UK Drug-DNA Interactions Research Group, UCL Cancer Institute, University College London, London, United Kingdom.
Timothy H WitneyCentre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom. tim.witney@kcl.ac.uk.ORCID 0000-0002-9475-2873
School of Advanced Study · GBUniversity College London · GBUniversity of Glasgow · GBCancer Research UK · GBCorlife (Germany) · DE

Funding

Cancer Research UK 16569Cancer Research UK 19702Cancer Research UK A16463Cancer Research UK A18088Cancer Research UK C53309/A19702Department of HealthWellcome Trust 107610
6 · The paper itself

Abstract

purposeDrug resistance is a major obstacle for the effective treatment of patients with high-grade serous ovarian cancer (HGSOC). Currently, there is no satisfactory way to identify patients with HGSOC that are refractive to the standard of care. Here, we propose the system x EXPERIMENTAL

designUsing matched chemotherapy sensitive and resistant ovarian cancer cell lines, we assessed their antioxidant capacity and its relation to [

resultsHigh intracellular glutathione (GSH) and low reactive oxygen species corresponded to decreased [

conclusionsThis study demonstrates the ability of [

Indexed as

BiomarkersDrug Resistance, NeoplasmPositron-Emission TomographyAnimalsAntineoplastic AgentsAntioxidantsCell Line, TumorCystineDisease Models, AnimalFemaleHumansMiceModels, BiologicalNeoplasm GradingOvarian NeoplasmsPositron Emission Tomography Computed TomographyAntineoplastic AgentsAntioxidantsBiomarkersCystineRadiopharmaceuticalsReactive Oxygen Species

Identifiers

PMID30651275
PMCPMC6522377
OpenAlexW2909261315

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.