Evidence map›Paper›PMID 30651226›Full record

ReviewClinical microbiology reviews2019

Treating Polymicrobial Infections in Chronic Diabetic Wounds.

Pranali J Buch, Yunrong Chai, Edgar D Goluch

Abstract readReview
In one paragraph

Review in Clinical microbiology reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pranali J BuchDepartment of Chemical Engineering, Northeastern University, Boston, Massachusetts, USA.
Yunrong ChaiDepartment of Biology, Northeastern University, Boston, Massachusetts, USA.
Edgar D GoluchDepartment of Chemical Engineering, Northeastern University, Boston, Massachusetts, USA e.goluch@northeastern.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review provides a comprehensive summary of issues associated with treating polyclonal bacterial biofilms in chronic diabetic wounds. We use this as a foundation and discuss the alternatives to conventional antibiotics and the emerging need for suitable drug delivery systems. In recent years, extraordinary advances have been made in the field of nanoparticle synthesis and packaging. However, these systems have not been incorporated into the clinic for treatments other than for cancer or severe genetic diseases. We present a unifying perspective on how the field is evolving and the need for an early amalgamation of engineering principles and a biological understanding of underlying phenomena in order to develop a therapy that is translatable to the clinic in a shorter time.

Indexed as

Anti-Bacterial AgentsBacterial InfectionsBiofilmsCoinfectionDiabetic FootDrug Delivery SystemsHumansAnti-Bacterial Agentsbiofilmschronic diabetic woundsdrug delivery systemsengineeringnanoparticlesquorum sensing

Identifiers

PMID30651226
PMCPMC6431129

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.