Evidence map›Paper›PMID 30651142›Full record

ArticleParasites & vectors2019

Evaluation of the in vitro and in vivo inhibitory effect of thymoquinone on piroplasm parasites.

Shimaa Abd El-Salam El-Sayed, Mohamed Abdo Rizk, Naoaki Yokoyama, Ikuo Igarashi

Abstract readEvaluation Study
In one paragraph

Article in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Could Mesquite (Animals : an open access journal from MDPI · 2025
    Review
  3. Article
  4. Review
  5. Pathogens and global health · 2023
    Article
  6. Article
  7. Article
  8. Evaluation of the Inhibitory Effect ofJournal of tropical medicine · 2023
    Article
  9. Antiparasitic activity of FLLL-32 against fourFrontiers in pharmacology · 2023
    Article
  10. Article
  11. Evaluation of theJournal of advanced veterinary and animal research · 2022
    Article
  12. Effect of methanolic extract fromVeterinary world · 2022
    Article
  13. Pomegranate (Journal of parasitology research · 2022
    Article
  14. Biomolecules · 2021
    Review
  15. Article
  16. Article
  17. Discovering the Potent Inhibitors AgainstFrontiers in veterinary science · 2021
    Article
  18. Review
  19. Review
  20. Myrrh OilPathogens (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shimaa Abd El-Salam El-SayedNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, Japan.
Mohamed Abdo RizkNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, Japan.
Naoaki YokoyamaNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, Japan.
Ikuo IgarashiNational Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-Cho, Obihiro, Hokkaido, Japan. igarcpmi@obihiro.ac.jp.

Funding

Japan Society for the Promotion of Science P18091Medicines for Malaria Venture not available
6 · The paper itself

Abstract

backgroundDeveloping new antibabesial drugs with a low toxic effect to the animal and with no resistance from Babesia parasites is in urgent demand. In this concern, the antimalarial, anticancer and antioxidant effect of thymoquinone (TQ), a phytochemical compound found in the plant Nigella sativa, has been reported. Therefore, in the present study, the antibabesial effect of this compound was evaluated on the growth of piroplasm parasites.

resultsSignificant inhibition (P < 0.05) of the in vitro growth of piroplasm parasites were observed after treatment by TQ with IC

conclusionsThe obtained results indicate that thymoquinone might be a promising medicinal compound for use in the treatment of animal piroplasmosis.

Indexed as

Administration, OralAnimalsAntiprotozoal AgentsBabesiaBabesiosisBenzoquinonesDiminazeneDisease Models, AnimalFemaleInhibitory Concentration 50MicePhytochemicalsTheileriaTheileriasisAntiprotozoal AgentsBenzoquinonesDiminazenediminazene aceturatePhytochemicalsthymoquinoneBabesiaIn vitroIn vivoTheileriaThymoquinone

Identifiers

PMID30651142
PMCPMC6335684

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.