Evidence map›Paper›PMID 30651140›Full record

ArticleEpigenetics & chromatin2019

The long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region.

Oriella Andresini, Marianna Nicoletta Rossi, Francesca Matteini, Stefano Petrai, Tiziana Santini, Rossella Maione

Open access · goldAbstract read
In one paragraph

Article in Epigenetics & chromatin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
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  7. Acta biochimica et biophysica Sinica · 2024
    Article
  8. Article
  9. Review
  10. Next RNA Therapeutics: The Mine of Non-Coding.International journal of molecular sciences · 2022
    Review
  11. Review
  12. Article
  13. Characterization of Long Non-coding RNAs Modified by mFrontiers in cell and developmental biology · 2021
    Article
  14. Review
  15. Association study betweenAnnals of translational medicine · 2021
    Article
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Oriella AndresiniDepartment of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
Marianna Nicoletta RossiRheumatology Unit, Bambino Gesu Children's Hospital (IRCCS), Viale di S. Paolo 15, 00146, Rome, Italy.
Francesca MatteiniDepartment of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
Stefano PetraiDepartment of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
Tiziana SantiniCenter for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161, Rome, Italy.
Rossella MaioneDepartment of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy. rossella.maione@uniroma1.it.
Sapienza University of Rome · ITItalian Institute of Technology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe cell-cycle inhibitor p57

resultsWe found that Kcnq1ot1 depletion by siRNA causes the upregulation of the maternal and functional p57

conclusionsThese findings highlight the existence of an imprinting-independent role of Kcnq1ot1, adding new insights into the biology of a still mysterious LncRNA. Moreover, they expand our knowledge about the molecular mechanisms underlying the tight and fine regulation of p57

Indexed as

Maternal InheritanceAnimalsCell DifferentiationCell LineCyclin-Dependent Kinase Inhibitor p57Genomic ImprintingHistonesMiceMice, Inbred C57BLMuscle CellsMyoD ProteinRNA, Long NoncodingCdkn1c protein, mouseCyclin-Dependent Kinase Inhibitor p57HistonesKCNQ1OT1 RNAMyoD ProteinRNA, Long NoncodingH3K27me3ImprintingKcnq1ot1Muscle differentiationMyoDp57kip2/Cdkn1c

Identifiers

PMID30651140
PMCPMC6334472
OpenAlexW2908786474

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.