ArticleSensors (Basel, Switzerland)2019
Surface Plasmon Enhanced Light Scattering Biosensing: Size Dependence on the Gold Nanoparticle Tag.
Article in Sensors (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Encapsulation of Citrate-Capped Gold Nanoparticles and Aqueous Solutions: Photophysical and Nonlinear Optical Properties and Elastic Scattering.Journal of fluorescence · 2025Article
- Systematic Study of Gold Nanoparticle Effects on the Performance and Stability of Perovskite Solar Cells.Nanomaterials (Basel, Switzerland) · 2025Article
- Phytochemical-assisted synthesis, optimization, and characterization of silver nanoparticles for antimicrobial activity.RSC advances · 2025Article
- Surface plasmon coupling between wide-field SPR microscopy and gold nanoparticles.Scientific reports · 2023Article
- Metamaterial Lensing Devices.Molecules (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
Surface plasmon enhanced light scattering (SP-LS) is a powerful new sensing SPR modality that yields excellent sensitivity in sandwich immunoassay using spherical gold nanoparticle (AuNP) tags. Towards further improving the performance of SP-LS, we systematically investigated the AuNP size effect. Simulation results indicated an AuNP size-dependent scattered power, and predicted the optimized AuNPs sizes (i.e., 100 and 130 nm) that afford extremely high signal enhancement in SP-LS. The maximum scattered power from a 130 nm AuNP is about 1700-fold higher than that obtained from a 17 nm AuNP. Experimentally, a bio-conjugation protocol was developed by coating the AuNPs with mixture of low and high molecular weight PEG molecules. Optimal IgG antibody bioconjugation conditions were identified using physicochemical characterization and a model dot-blot assay. Aggregation prevented the use of the larger AuNPs in SP-LS experiments. As predicted by simulation, AuNPs with diameters of 50 and 64 nm yielded significantly higher SP-LS signal enhancement in comparison to the smaller particles. Finally, we demonstrated the feasibility of a two-step SP-LS protocol based on a gold enhancement step, aimed at enlarging 36 nm AuNPs tags. This study provides a blue-print for the further development of SP-LS biosensing and its translation in the bioanalytical field.
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