Evidence map›Paper›PMID 30650575›Full record

ArticleInternational journal of molecular sciences2019

Identification of Cerebrospinal Fluid Metabolites as Biomarkers for Enterovirus Meningitis.

Dominica Ratuszny, Kurt-Wolfram Sühs, Natalia Novoselova, Maike Kuhn, Volkhard Kaever, Thomas Skripuletz, Frank Pessler, Martin Stangel

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Dominica RatusznyClinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. Ratuszny.Dominica@mh-hannover.de.
Kurt-Wolfram SühsClinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. Suehs.Kurt-Wolfram@mh-hannover.de.ORCID 0000-0002-8077-481X
Natalia NovoselovaInstitute for Experimental Infection Research, TWINCORE Centre for Experimental and Clinical Infection Research GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany. novos65@mail.ru.
Maike KuhnInstitute for Experimental Infection Research, TWINCORE Centre for Experimental and Clinical Infection Research GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany. maike.kuhn@t-online.de.
Volkhard KaeverResearch Core Unit Metabolomics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. kaever.volkhard@mh-hannover.de.
Thomas SkripuletzClinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. Skripuletz.Thomas@mh-hannover.de.
Frank PesslerCentre for Individualised Infection Medicine, Feodor-Lynen-Str. 15, 30625 Hannover, Germany. Stangel.Martin@mh-hannover.de.
Martin StangelClinical Neuroimmunology and Neurochemistry, Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. frank.pessler@twincore.de.ORCID 0000-0003-2504-5398
Medizinische Hochschule Hannover · DEHelmholtz Centre for Infection Research · DENational Academy of Sciences of Belarus · BY

Funding

Deutsche Forschungsgemeinschaft Cluster of Excelence RESISTHelmholtz Association iMed Initiative on Personalized MedicineMedizinischen Hochschule Hannover Junge Akademie
6 · The paper itself

Abstract

Enteroviruses are among the most common causes of viral meningitis. Enteroviral meningitis continues to represent diagnostic challenges, as cerebrospinal fluid (CSF) cell numbers (a well validated diagnostic screening tool) may be normal in up to 15% of patients. We aimed to identify potential CSF biomarkers for enteroviral meningitis, particularly for cases with normal CSF cell count. Using targeted liquid chromatography-mass spectrometry, we determined metabolite profiles from patients with enteroviral meningitis (

Indexed as

MetabolomeAdultAgedAlgorithmsBiomarkersEnterovirus InfectionsFemaleHumansMaleMass SpectrometryMeningitis, ViralMiddle AgedReproducibility of ResultsYoung AdultBiomarkersbiomarkercerebrospinal fluidCNS infectionenterovirusmeningitismetabolomicsphosphatidylcholines

Identifiers

PMID30650575
PMCPMC6359617
OpenAlexW2909770847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.