Evidence map›Paper›PMID 30650553›Full record

ArticleNutrients2019

Donato F Romagnolo, Micah G Donovan, Tom C Doetschman, Ornella I Selmin

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Fatty acids and epigenetics in health and diseases.Food science and biotechnology · 2024
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Pleiotropic roles of FXR in liver and colorectal cancers.Molecular and cellular endocrinology · 2022
    Article
  18. Article
  19. Article
  20. International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Donato F RomagnoloThe University of Arizona Cancer Center, Tucson, AZ 85724, USA. donato@u.arizona.edu.
Micah G DonovanInterdisciplinary Cancer Biology Graduate Program, University of Arizona, Tucson, AZ 85724, USA. mdono123@email.arizona.edu.
Tom C DoetschmanDepartment of Cellular & Molecular Medicine, University of Arizona, Tucson, AZ 85724, USA. tdoetsch@email.arizona.edu.
Ornella I SelminThe University of Arizona Cancer Center, Tucson, AZ 85724, USA. selmin@email.arizona.edu.
University of Arizona · USUniversity of Arizona Cancer Center

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
Integrative Cancer Scholars Training GrantT32CA009213 · NCI · UNIVERSITY OF ARIZONA · PI CAREW, JENNIFER S, CURIEL-LEWANDROWSKI, CLARA · 1985 to 2024
$8.6M
NCI NIH HHS P30CA23074NCI NIH HHS T32 CA009213NCI NIH HHS T32CA009213
6 · The paper itself

Abstract

The farnesoid-X-receptor (FXR) protects against inflammation and cancer of the colon through maintenance of intestinal bile acid (BA) homeostasis. Conversely, higher levels of BA and cyclooxygenase-2 (COX-2) are risk factors for inflammation and cancer of the colon. In the United States,

Indexed as

Epigenesis, GeneticAdenomatous Polyposis Coli ProteinAnimalsBile Acids and SaltsCells, CulturedColitisColonColonic NeoplasmsCyclin D1Cyclooxygenase 2Dietary FatsDiet, High-FatDNA MethylationFetal ResearchGenes, junHumansAdenomatous Polyposis Coli ProteinAPC protein, humanBile Acids and SaltsCCND1 protein, humanCyclin D1Cyclooxygenase 2Dietary FatsFXR1 protein, humanLinoleic AcidPTGS2 protein, humanRNA-Binding ProteinsApcbile acidscolon cancercyclooxygenase-2 (COX-2)epigeneticsfarnesoid-X-receptor (FXR)high-fat diet (HFD)n-6 linoleic acid

Identifiers

PMID30650553
PMCPMC6356359
OpenAlexW2909903598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.