ArticleImmunity2019
Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology.
Open access · bronzeAbstract read
In one paragraph
Article in Immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 71 citations in OpenAlex.
- Cellular metabolism in Th9, Th17, and Treg cell differentiation.International immunology · 2025Review
- Nuclear receptor coregulator NRIP1 R448G modulates T cell gut homing to control intestinal inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Maternal Folic Acid Supplementation, Perinatal Factors, and Pre-Adolescent Asthma: Findings from the Healthy Growth Study.Nutrients · 2025Article
- Genomic regions occupied by both RARα and VDR are involved in the convergence and cooperation of retinoid and vitamin D signaling pathways.Nucleic acids research · 2025Article
- Novel drug research and therapeutic strategies targeting tumor metastasis and cancer stem cells.Frontiers in pharmacology · 2025Review
- Metabolic regulation of Th9 cell differentiation: insights for IL-9-driven diseases.Frontiers in immunology · 2025Review
- Regulatory mechanisms of Th9 cell differentiation.Frontiers in immunology · 2025Review
- Fatty acid metabolism constrains Th9 cell differentiation and antitumor immunity via the modulation of retinoic acid receptor signaling.Cellular & molecular immunology · 2024Article
- Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease.Experimental & molecular medicine · 2024Review
- Metabolic waypoints during T cell differentiation.Nature immunology · 2024Review
- Immunologic aspects of asthma: from molecular mechanisms to disease pathophysiology and clinical translation.Frontiers in immunology · 2024Review
- International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023.Pharmacological reviews · 2023Review
- The World according to IL-9.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- JAKing up IL-9 expression in TNature immunology · 2023Article
- Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TNature immunology · 2023Article
- Three-dimensional genome organization in immune cell fate and function.Nature reviews. Immunology · 2023Review
- The Differentially Expressed Genes Responsible for the Development of T Helper 9 Cells From T Helper 2 Cells in Various Disease States: Immuno-Interactomics Study.JMIR bioinformatics and biotechnology · 2023Article
- Activation of the RARα Attenuated CSF Hypersecretion to Inhibit Hydrocephalus Development via Regulating the MAFB/MSR1 Pathway.International journal of molecular sciences · 2023Article
- From thymus to tissues and tumors: A review of T-cell biology.The Journal of allergy and clinical immunology · 2023Review
- Insights into vitamin A in bladder cancer, lack of attention to gut microbiota?Frontiers in immunology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 4 institutions in 2 countries.
Daniella M SchwartzMolecular Immunology and Inflammation Branch, NIAMS, NIH, Rockville, MD 20892, USA; Genenetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, NIAID, NIH, Rockville, MD 20892, USA. Electronic address: daniella.schwartz@nih.gov.
Taylor K FarleyImmunoregulation Section, Autoimmunity Branch, NIAMS, NIH, Rockville, MD 20892, USA; Metaorganism Immunity Section, Laboratory of Immune System Biology, NIAID, NIH, Rockville, MD 20892, USA.
Nathan RichozImmunoregulation Section, Autoimmunity Branch, NIAMS, NIH, Rockville, MD 20892, USA.
Chen YaoMolecular Immunology and Inflammation Branch, NIAMS, NIH, Rockville, MD 20892, USA.
Han-Yu ShihMolecular Immunology and Inflammation Branch, NIAMS, NIH, Rockville, MD 20892, USA.
Franziska PetermannMolecular Immunology and Inflammation Branch, NIAMS, NIH, Rockville, MD 20892, USA.
Yuan ZhangGenenetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, NIAID, NIH, Rockville, MD 20892, USA.
Hong-Wei SunOffice of Science and Technology, NIAMS, NIH, Rockville, MD 20892, USA.
Erika HayesImmunoregulation Section, Autoimmunity Branch, NIAMS, NIH, Rockville, MD 20892, USA.
Yohei MikamiMolecular Immunology and Inflammation Branch, NIAMS, NIH, Rockville, MD 20892, USA.
Kan JiangMolecular Immunology and Inflammation Branch, NIAMS, NIH, Rockville, MD 20892, USA.
Fred P DavisMolecular Immunology and Inflammation Branch, NIAMS, NIH, Rockville, MD 20892, USA.
Yuka KannoMolecular Immunology and Inflammation Branch, NIAMS, NIH, Rockville, MD 20892, USA.
Joshua D MilnerGenenetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, NIAID, NIH, Rockville, MD 20892, USA.
Richard SiegelImmunoregulation Section, Autoimmunity Branch, NIAMS, NIH, Rockville, MD 20892, USA.
Arian LaurenceTranslational Gastroenterology Unit, Experimental Medicine Division, John Radcliffe Hospital, University of Oxford, UK.
Françoise MeylanImmunoregulation Section, Autoimmunity Branch, NIAMS, NIH, Rockville, MD 20892, USA.
John J O'SheaMolecular Immunology and Inflammation Branch, NIAMS, NIH, Rockville, MD 20892, USA.
National Institute of Arthritis and Musculoskeletal and Skin Diseases · USNational Institute of Allergy and Infectious Diseases · USOffice of Science · USUniversity of Oxford · GB
Funding
Stat transcription factors in immunoregulation and autoimmune diseaseZIAAR041159 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI O'SHEA, JOHN · 2009 to 2025
$49.3MApplying Bioinformatics to Research in Immune, Muscle, and Bone DiseasesZIHAR041173 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI GADINA, MASSIMO · 2009 to 2020
$11.0MThe Regulation and Roles of Atopic Cytokines in Autoimmune and Auto Inflammatory DiseasesZIAAI001251 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SCHWARTZ, DANIELLA · 2019 to 2022
$1.9MIntramural NIH HHS Z99 AI999999
Abstract
CD4
Indexed as
AnimalsEpigenetic RepressionHEK293 CellsHumansHypersensitivityInterleukin-9LungMiceMice, Inbred C57BLMice, KnockoutPneumoniaRetinoic Acid Receptor alphaSignal TransductionT-Lymphocytes, Helper-InducerTranscription, GeneticTretinoinInterleukin-9Retinoic Acid Receptor alphaTretinoinATAC-seqChIP-seqEnhancersInterleukin 9InterleukinsRetinoic acidRNA sequencingTh9 cellsT helper cellsvitamin A
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.