Evidence map›Paper›PMID 30650369›Full record

ArticleImmunity2019

RIPK3: Beyond Necroptosis.

Azia S Evans, Carolyn B Coyne

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. The regulatory role of Pin1 in neuronal death.Neural regeneration research · 2023
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Azia S EvansDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Microbial Pathogenesis, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Carolyn B CoyneDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Microbial Pathogenesis, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA; R. K. Mellon Institute for Pediatric Research, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address: coynec2@pitt.edu.
University of Pittsburgh · US

Funding

Enterovirus Infection of Polarized Intestinal CellsR01AI081759 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COYNE, CAROLYN B · 2009 to 2024
$5.0M
6 · The paper itself

Abstract

In this issue of Immunity, Daniels et al. (2019) demonstrate that RIPK3 signaling limits Zika virus (ZIKV) infection in the central nervous system independently of its function in necroptosis by promoting itaconate production in infected neurons, thereby revealing a neuron-specific mechanism of metabolite-mediated ZIKV control.

Indexed as

Antiviral AgentsZika VirusZika Virus InfectionApoptosisCarboxy-LyasesHumansNecrosisNeuronsNucleotidesProteinsReceptor-Interacting Protein Serine-Threonine KinasesACOD1 protein, humanAntiviral AgentsCarboxy-LyasesNucleotidesProteinsReceptor-Interacting Protein Serine-Threonine KinasesRIPK3 protein, human

Identifiers

PMID30650369
OpenAlexW2911195480

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.