ArticleAngewandte Chemie (International ed. in English)2019
Enantioconvergent Cross-Couplings of Alkyl Electrophiles: The Catalytic Asymmetric Synthesis of Organosilanes.
Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Recent progress on Ni-catalysed alkyl-alkyl cross-coupling enabled by asymmetric hydrofunctionalization of alkenes.Chemical science · 2026Review
- Nickel-Catalyzed Enantioconvergent Arylation of Unactivated Cyclic Electrophiles: Asymmetric Synthesis of 3-Substituted Pyrrolidines.Angewandte Chemie (International ed. in English) · 2026Article
- Three-Coordinate Iron(0) Complex-Catalyzed Regioselective C-H Alkylation of Indole Derivatives.Journal of the American Chemical Society · 2025Article
- CFNature communications · 2025Article
- Nickel-Catalyzed Enantio- and Diastereoselective Synthesis of Fluorine-Containing Vicinal Stereogenic Centers.ACS central science · 2024Article
- Ni(2,2':6',2''-terpyridine)Dalton transactions (Cambridge, England : 2003) · 2024Article
- Fully Automated Flow Protocol for C(spOrganic letters · 2024Article
- Metal-Catalyzed Enantioconvergent Transformations.Chemical reviews · 2023Review
- Ruthenium(II)/Imidazolidine Carboxylic Acid-Catalyzed C-H Alkylation for Central and Axial Double Enantio-Induction.Angewandte Chemie (International ed. in English) · 2022Article
- DFT insight into asymmetric alkyl-alkyl bond formationChemical science · 2022Article
- Direct synthesis and applications of solid silylzinc reagents.Chemical science · 2021Article
- Enantio- and Regioconvergent Nickel-Catalyzed C(spAngewandte Chemie (International ed. in English) · 2021Article
- Beyond Carbon: Enantioselective and Enantiospecific Reactions with Catalytically Generated Boryl- and Silylcopper Intermediates.ACS central science · 2020Review
- Stereospecific and Chemoselective Copper-Catalyzed Deaminative Silylation of Benzylic Ammonium Triflates.Angewandte Chemie (International ed. in English) · 2020Article
- A general asymmetric copper-catalysed Sonogashira C(spNature chemistry · 2019Article
- Article
- Photochemical Asymmetric Nickel-Catalyzed Acyl Cross-Coupling.Angewandte Chemie (International ed. in English) · 2019Article
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3 authors.
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Abstract
Metal-catalyzed enantioconvergent cross-coupling reactions of alkyl electrophiles are emerging as a powerful tool in asymmetric synthesis. To date, high enantioselectivity has been limited to couplings of electrophiles that bear a directing group or a proximal p/π orbital. Herein, we demonstrate for the first time that enantioconvergent cross-couplings can be achieved with electrophiles that lack such features; specifically, we establish that a chiral nickel catalyst can accomplish Negishi reactions of racemic α-halosilanes with alkylzinc reagents with good enantioselectivity under simple and mild conditions, thereby providing access to enantioenriched organosilanes, an important class of target molecules.
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