ArticlePloS one2019
LittleBrain: A gradient-based tool for the topographical interpretation of cerebellar neuroimaging findings.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- A bias-accounting meta-analytic approach refines and expands the cerebellar behavioral topography.Neuroscience and biobehavioral reviews · 2025Pooled it
- Differential vulnerability of the cerebellum in healthy ageing and Alzheimer's disease.NeuroImage. Clinical · 2021Pooled it
- A Digital Anatomical Atlas of the Human Cerebellum at Subfolial Resolution.Human brain mapping · 2026Article
- Functional connectivity patterns of the cerebellar components of intrinsic connectivity networks in clinically diagnosed probable Alzheimer's disease.BMC medical imaging · 2026Article
- Functional development of the human cerebellum from birth to age five.Nature communications · 2025Article
- A bias-accounting meta-analytic approach refines and expands the cerebellar behavioral topography.bioRxiv : the preprint server for biology · 2025Article
- Gradients of Brain Organization: Smooth Sailing from Methods Development to User Community.Neuroinformatics · 2024Review
- Population-wide cerebellar growth models of children and adolescents.Nature communications · 2024Article
- aXonica: A support package for MRI based Neuroimaging.Biotechnology notes (Amsterdam, Netherlands) · 2024Article
- Variations on the theme: focus on cerebellum and emotional processing.Frontiers in systems neuroscience · 2023Review
- Functional Gradients of the Cerebellum: a Review of Practical Applications.Cerebellum (London, England) · 2022Review
- Distinct alterations in cerebellar connectivity with substantia nigra and ventral tegmental area in Parkinson's disease.Scientific reports · 2022Article
- Increased resting-state activity in the cerebellum with mothers having less adaptive sensory processing and trait anxiety.Human brain mapping · 2021Article
- Article
- The detailed organization of the human cerebellum estimated by intrinsic functional connectivity within the individual.Journal of neurophysiology · 2021Article
- Article
- Cerebellar contributions to rapid semantic processing in reading.Brain and language · 2020Article
- BrainSpace: a toolbox for the analysis of macroscale gradients in neuroimaging and connectomics datasets.Communications biology · 2020Article
- Altered resting-state functional connectivity in young children at familial high risk for psychotic illness: A preliminary study.Schizophrenia research · 2020Article
- Neurodevelopmental and Psychiatric Symptoms in Patients with a Cyst Compressing the Cerebellum: an Ongoing Enigma.Cerebellum (London, England) · 2020Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Gradient-based approaches to brain function have recently unmasked fundamental properties of brain organization. Diffusion map embedding analysis of resting-state fMRI data revealed a primary-to-transmodal axis of cerebral cortical macroscale functional organization. The same method was recently used to analyze resting-state data within the cerebellum, revealing for the first time a sensorimotor-fugal macroscale organization principle of cerebellar function. Cerebellar gradient 1 extended from motor to non-motor task-unfocused (default-mode network) areas, and cerebellar gradient 2 isolated task-focused processing regions. Here we present a freely available and easily accessible tool that applies this new knowledge to the topographical interpretation of cerebellar neuroimaging findings. LittleBrain illustrates the relationship between cerebellar data (e.g., volumetric patient study clusters, task activation maps, etc.) and cerebellar gradients 1 and 2. Specifically, LittleBrain plots all voxels of the cerebellum in a two-dimensional scatterplot, with each axis corresponding to one of the two principal functional gradients of the cerebellum, and indicates the position of cerebellar neuroimaging data within these two dimensions. This novel method of data mapping provides alternative, gradual visualizations that complement discrete parcellation maps of cerebellar functional neuroanatomy. We present application examples to show that LittleBrain can also capture subtle, progressive aspects of cerebellar functional neuroanatomy that would be difficult to visualize using conventional mapping techniques. Download and use instructions can be found at https://xaviergp.github.io/littlebrain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.