Evidence map›Paper›PMID 30649923›Full record

ReviewAnnual review of biochemistry2019

Molecular Mechanism of Cytokinesis.

Thomas D Pollard, Ben O'Shaughnessy

Abstract readReview
In one paragraph

Review in Annual review of biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Cell cycle in plant development and reprogramming.Development (Cambridge, England) · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Semi-automated Detection of Late Cytokinetic Bridges.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Thomas D PollardDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520-8103, USA; email: thomas.pollard@yale.edu.
Ben O'ShaughnessyDepartment of Chemical Engineering, Columbia University, New York, NY 10027, USA; email: bo8@columbia.edu.

Funding

Mechanism of cytokinesis in fission yeastR01GM026132 · NIGMS · YALE UNIVERSITY · PI POLLARD, THOMAS D. · 1985 to 2021
$8.8M
Modeling Contractile Ring Constriction in Fission YeastR01GM086731 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI O'SHAUGHNESSY, BEN · 2010 to 2019
$2.8M
NIGMS NIH HHS R01 GM026132NIGMS NIH HHS R01 GM086731
6 · The paper itself

Abstract

Division of amoebas, fungi, and animal cells into two daughter cells at the end of the cell cycle depends on a common set of ancient proteins, principally actin filaments and myosin-II motors. Anillin, formins, IQGAPs, and many other proteins regulate the assembly of the actin filaments into a contractile ring positioned between the daughter nuclei by different mechanisms in fungi and animal cells. Interactions of myosin-II with actin filaments produce force to assemble and then constrict the contractile ring to form a cleavage furrow. Contractile rings disassemble as they constrict. In some cases, knowledge about the numbers of participating proteins and their biochemical mechanisms has made it possible to formulate molecularly explicit mathematical models that reproduce the observed physical events during cytokinesis by computer simulations.

Indexed as

CytokinesisActinsAnimalsCell CycleEukaryotaHumansModels, BiologicalMyosinsSignal TransductionSpindle ApparatusYeastsActinsMyosinsactincontractile ringcytokinesismathematical modelsmyosin

Identifiers

PMID30649923
PMCPMC6588489

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.