ArticleAmerican journal of physiology. Renal physiology2019
Zinc deficiency induces hypertension by promoting renal Na
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
4.2field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Blood trace element concentrations and adult hypertension: A systematic review and meta-analysis of observational studies.Environmental science and pollution research international · 2026Pooled it
- Genetic determinants of zinc homeostasis and its role in cardiometabolic diseases.PLoS genetics · 2025Pooled it
- Maternal Serum Zinc Level and Pre-eclampsia Risk in African Women: a Systematic Review and Meta-analysis.Biological trace element research · 2021Pooled it
- Trace Element and Mineral Levels in Serum, Hair, and Urine of Obese Women in Relation to Body Composition, Blood Pressure, Lipid Profile, and Insulin Resistance.Biomolecules · 2021Trial
- Zinc deficiency and antihypertensive treatment intensity in patients initiating dialysis: a cross-sectional analysis from the Jikei hemodialysis and peritoneal dialysis study (JHPS).Clinical and experimental nephrology · 2026Article
- Association between serum zinc levels and new-onset hypertension: A 5-year retrospective cohort study.Medicine · 2026Article
- Risk of Zinc Deficiency from Urinary Zinc Loss Induced by Antihypertensive Drugs: A Narrative Review.Biological trace element research · 2026Review
- Zinc deficiency contributes to blunted myogenesis in chronic kidney disease.American journal of physiology. Cell physiology · 2026Article
- The Role of the Gut Microbiota in Vascular Physiology and Health.International journal of molecular sciences · 2025Review
- SLC39A8-mediated zinc dyshomeostasis potentiates kidney disease.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Zinc deficiency as possible link between immunosenescence and age-related diseases.Immunity & ageing : I & A · 2025Review
- Renal Ghrelin-Family GPR39 Receptor and Urinary Concentrating Ability.Journal of the American Society of Nephrology : JASN · 2025Article
- Effects of zinc in podocytes and cortical collecting duct in vitro and Dahl salt-sensitive rats in vivo.The Journal of biological chemistry · 2024Article
- Article
- Strategies for inducing and validating zinc deficiency and zinc repletion.American journal of physiology. Heart and circulatory physiology · 2024Article
- Strategies for Inducing and Validating Zinc Deficiency and Zinc Repletion.bioRxiv : the preprint server for biology · 2024Article
- Contaminant Metals and Cardiovascular Health.Journal of cardiovascular development and disease · 2023Review
- Interactive Effects of Obesity and Hypertension on Patterns of Hair Essential Trace Element and Mineral Content in Adult Women.Biological trace element research · 2023Article
- Selenium deficiency causes hypertension by increasing renal ATFree radical biology & medicine · 2023Article
- Cardiovascular Diseases and Zinc.Biological trace element research · 2023Review
Corrections and comments
- Erratum issuedCORRIGENDUM.2019
Authors and funding
12 authors at 3 institutions in 1 country.
Clintoria R WilliamsDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University , Atlanta, Georgia.
Monisha MistryDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University , Atlanta, Georgia.
Aswathy M CheriyanDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University , Atlanta, Georgia.
Jasmine M WilliamsDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University , Atlanta, Georgia.
Meagan K NaraineDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University , Atlanta, Georgia.
Carla L EllisDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University , Atlanta, Georgia.
Rickta MallickDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University , Atlanta, Georgia.
Abinash C MistryDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University , Atlanta, Georgia.
Jennifer L GoochDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University , Atlanta, Georgia.
Benjamin KoDepartment of Medicine, University of Chicago , Chicago, Illinois.
Hui CaiDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University , Atlanta, Georgia.
Robert S HooverDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University , Atlanta, Georgia.
Emory University · USVeterans Health Administration · USUniversity of Chicago · US
Funding
Nephrology Institutional Training Grant FLSA SupplementT32DK007656 · NIDDK · EMORY UNIVERSITY · PI SANDS, JEFF M, WALL, SUSAN MARIE · 1990 to 2020
$3.5MMechanisms of Hormonal Regulation of the Sodium Chloride CotransporterR01DK085097 · NIDDK · EMORY UNIVERSITY · PI HOOVER, ROBERT S · 2010 to 2015
$1.5MSummer Undergraduate Program in Emory Renal Research (SUPERR)R25DK101390 · NIDDK · EMORY UNIVERSITY · PI Jason Cobb, Jeanie Park · 2014 to 2026
$1.4MNCC and ENaC form a Sodium Transporting ComplexI01BX002322 · VA · VETERANS HEALTH ADMINISTRATION · PI HOOVER, ROBERT S · 2016 to 2020
–BLRD VA I01 BX002322NIDDK NIH HHS R01 DK085097NIDDK NIH HHS R25 DK101390NIDDK NIH HHS T32 DK007656
Abstract
Zn
Indexed as
AnimalsBlood PressureCells, CulturedChelating AgentsDietEthylenediaminesHydrochlorothiazideHypertensionKidneyKidney Tubules, DistalMiceMice, Inbred C57BLNatriuresisSodiumSodium Chloride Symporter InhibitorsZincChelating AgentsEthylenediaminesHydrochlorothiazideN,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamineSodiumSodium Chloride Symporter InhibitorsZincblood pressurehypertensionkidneysodium-chloride cotransporterzinc deficiency
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.