Evidence map›Paper›PMID 30649877›Full record

ArticleBioconjugate chemistry2019

Optimization of Enzymatic Antibody Fragmentation for Yield, Efficiency, and Binding Affinity.

Andrew W L Kinman, Rebecca R Pompano

Open access · greenAbstract read
In one paragraph

Article in Bioconjugate chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Methods for Conjugating Antibodies with Quantum Dots.Molecules (Basel, Switzerland) · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Modulating the RAGE-Induced Inflammatory Response: Peptoids as RAGE Antagonists.Chembiochem : a European journal of chemical biology · 2023
    Article
  12. Antibody Phage Display.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Removal of Fc Glycans from [Molecular pharmaceutics · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Andrew W L KinmanDepartment of Chemistry , University of Virginia , P.O. Box 400319, Charlottesville , Virginia 22904 , United States.ORCID 0000-0002-5107-2210
Rebecca R PompanoDepartment of Chemistry , University of Virginia , P.O. Box 400319, Charlottesville , Virginia 22904 , United States.ORCID 0000-0002-8644-9313
University of Virginia · US

Funding

Modeling immunity with a hybrid lymph node tissue-chipR01AI131723 · NIAID · UNIVERSITY OF VIRGINIA · PI POMPANO, REBECCA R · 2018 to 2022
$2.3M
NIAID NIH HHS R01 AI131723
6 · The paper itself

Abstract

Enzymatic antibody fragmentation has been well studied for various hosts and isotypes, but fragmentation patterns also vary unpredictably by clone, and optimizing Fab or F(ab')

Indexed as

AnimalsAntibodiesAntibody AffinityHydrogen-Ion ConcentrationImmunoglobulin Fab FragmentsPepsin AAntibodiesImmunoglobulin Fab FragmentsPepsin A

Identifiers

PMID30649877
PMCPMC6718091
OpenAlexW2909741835

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.