Evidence map›Paper›PMID 30649859›Full record

ArticleACS nano2019

In Situ Generation of Chiroptically-Active Gold-Peptide Superstructures Promoted by Iodination.

Claudia Pigliacelli, Kavitha Buntara Sanjeeva, Nonappa, Andrea Pizzi, Alessandro Gori, Francesca Baldelli Bombelli, Pierangelo Metrangolo

Abstract read
In one paragraph

Article in ACS nano, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Site-SpecificACS nano · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Imparting Stability to Chiral Helical Gold Nanoparticle Superstructures.Langmuir : the ACS journal of surfaces and colloids · 2024
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Chiral Supraparticles for Controllable Nanomedicine.Advanced materials (Deerfield Beach, Fla.) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Claudia PigliacelliHyber Center of Excellence, Department of Applied Physics , Aalto University , Puumiehenkuja 2 , FI-00076 Espoo , Finland.ORCID 0000-0002-0143-9045
Kavitha Buntara SanjeevaLaboratory of Supramolecular and Bio-Nanomaterials (SBNLab), Department of Chemistry, Materials, and Chemical Engineering "Giulio Natta" , Politecnico di Milano , via L. Mancinelli 7 , 20131 Milano , Italy.ORCID 0000-0001-6470-2202
NonappaHyber Center of Excellence, Department of Applied Physics , Aalto University , Puumiehenkuja 2 , FI-00076 Espoo , Finland.ORCID 0000-0002-6804-4128
Andrea PizziLaboratory of Supramolecular and Bio-Nanomaterials (SBNLab), Department of Chemistry, Materials, and Chemical Engineering "Giulio Natta" , Politecnico di Milano , via L. Mancinelli 7 , 20131 Milano , Italy.ORCID 0000-0002-4180-9151
Alessandro GoriIstituto di Chimica del Riconoscimento Molecolare, CNR , via M. Bianco 9 , 20131 Milano , Italy.ORCID 0000-0003-1640-7238
Francesca Baldelli BombelliLaboratory of Supramolecular and Bio-Nanomaterials (SBNLab), Department of Chemistry, Materials, and Chemical Engineering "Giulio Natta" , Politecnico di Milano , via L. Mancinelli 7 , 20131 Milano , Italy.ORCID 0000-0001-8138-9246
Pierangelo MetrangoloHyber Center of Excellence, Department of Applied Physics , Aalto University , Puumiehenkuja 2 , FI-00076 Espoo , Finland.ORCID 0000-0002-7945-099X

Funding

European Research Council 307108
6 · The paper itself

Abstract

Peptide-mediated routes to the synthesis of plasmonic nanoparticles have been drawing increasing attention for the development of chiroptically active nanoscale architectures. However, designing a multifunctional peptide able to drive the formation of structurally defined nanomaterials endowed with specific functionalities is still challenging. In this work, iodination has been devised as a strategy to strengthen Au-reduction capability of the amyloidogenic peptide DFNKF and combine it with its distinctive self-assembly features. Thanks to the Au-mediated C-I activation on the phenylalanine iodobenzenes, the peptides yield efficient Au-reduction ability promoting the synthesis of Au nanoparticles, and simultaneously working as templates for their spontaneous self-assembly into spherical superstructures endowed with chiroptical activities. The reaction occurs in situ through a one-pot process in aqueous media. The generality of this approach has been demonstrated using an iodinated derivative of the peptide KLVFF, which also showed reducing and templating abilities forming chiroptically active helical superstructures decorated with Au nanoparticles.

Indexed as

GoldHalogenationMetal NanoparticlesMolecular StructureParticle SizePeptidesSurface PropertiesGoldPeptideschiropticalgoldiodinenanoparticlespeptidesuperstructures

Identifiers

PMID30649859
PMCPMC6396319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.