ArticleMetabolic brain disease2019
Increases in total cholesterol and low density lipoprotein associated with decreased cognitive performance in healthy elderly adults.
Article in Metabolic brain disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Association Between Serum Lipid Traits and Cognitive Function in Middle-aged and Elderly Adults: A Longitudinal Study.Current Alzheimer research · 2025Article
- Causal links between obesity, lipids, adipokines, and cognition: a bidirectional Mendelian-randomization analysis.Frontiers in endocrinology · 2025Article
- Association between weight-adjusted waist circumference index and risk of cognitive decline in Chinese hypertensive patients: a case-control study.Frontiers in public health · 2025Article
- Large-scale functional network connectivity mediates the associations between lipids metabolism and cognition in type 2 diabetes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Perceived health- related quality of life in persons with multiple sclerosis with and without a vascular comorbidity.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Digital neuropsychological measures by defense automated neurocognitive assessment: reference values and clinical correlates.Frontiers in neurology · 2024Article
- Potential role of TREM2 in high cholesterol‑induced cell injury and metabolic dysfunction in SH‑SY5Y cells.Experimental and therapeutic medicine · 2023Article
- The factors associated with cognitive function among community-dwelling older adults in Taiwan.BMC geriatrics · 2023Observational
- Deep transfer learning of structural magnetic resonance imaging fused with blood parameters improves brain age prediction.Human brain mapping · 2022Article
- Potential Value of Serum Lipid in the Identication of Postoperative Delirium Undergoing Knee/Hip Arthroplasty: The Perioperative Neurocognitive Disorder and Biomarker Lifestyle Study.Frontiers in psychiatry · 2022Article
- An impact of lipid profile and lipid lowering drugs on ≥70 year olds of an upper socioeconomic class: a retrospective cohort study.Lipids in health and disease · 2021Article
- Long-Term Increase in Cholesterol Is Associated With Better Cognitive Function: Evidence From a Longitudinal Study.Frontiers in aging neuroscience · 2021Article
- Preoperative assessment of cognitive function and risk assessment of cognitive impairment in elderly patients with orthopedics: a cross-sectional study.BMC anesthesiology · 2020Article
- Associations of Lipid Levels and Cognition: Findings from the Hispanic Community Health Study/Study of Latinos.Journal of the International Neuropsychological Society : JINS · 2020Article
- Large-Scale Internetwork Functional Connectivity Mediates the Relationship between Serum Triglyceride and Working Memory in Young Adulthood.Neural plasticity · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current study examined associations between blood lipid profiles and cognitive functioning using a healthy non-demented elderly sample. The sample comprised 196 healthy volunteers (male; 86: female 110) aged 60-75 years from the Australian Research Council Longevity Intervention (ARCLI) study cohort. Serum total cholesterol (T-C), low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol (HDL-c) and triglycerides (TGL) were collected, and participants completed the Swinburne University Computerized Cognitive Assessment Battery (SUCCAB). In line with prediction, higher levels of T-C and LDL-c were found to be associated with impaired speeds of response in tasks assessing recognition memory, working memory and inhibitory processing. However, contrary to prediction both TGL and HDL-c were found to be unrelated to cognitive functioning in the current sample. It is suggested that frontal lobe function may be differentially sensitive to the effects of T-C and LDL-c accumulation during the aging process. Future data collection as part of the larger ARCLI intervention study will provide important follow-up data regarding the ability of the baseline blood lipid data to predict subsequent cognitive change.
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