Evidence map›Paper›PMID 30649660›Full record

ReviewImmunologic research2019

Macrophage phenotype bioengineered by magnetic, genetic, or pharmacologic interference.

Jarek Wosik, Martha Suarez-Villagran, John H Miller, Rafik M Ghobrial, Malgorzata Kloc

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Macrophage Actin Cytoskeleton in Chronic Rejection.Results and problems in cell differentiation · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in Osteoarthritis.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jarek WosikElectrical and Computer Engineering Department, University of Houston, Houston, TX, 77204, USA. jarek@uh.edu.
Martha Suarez-VillagranElectrical and Computer Engineering Department, University of Houston, Houston, TX, 77204, USA.
John H MillerElectrical and Computer Engineering Department, University of Houston, Houston, TX, 77204, USA.
Rafik M GhobrialThe Houston Methodist Research Institute, Houston, TX, 77030, USA.
Malgorzata KlocThe Houston Methodist Research Institute, Houston, TX, 77030, USA. mkloc@houstonmethodist.org.ORCID 0000-0002-5192-8584
University of Houston · USHouston Methodist · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In all eukaryotes, the cell shape depends on the actin filament cytoskeleton, which is regulated by the small GTPase RhoA. It is well known that the cell shape determines cell function and behavior. Inversely, any change in the cell behavior and/or function reverberates at the cell shape. In this review, we describe how mechanical/magnetic, genetic, or pharmacologic interference with the actin cytoskeleton enforces changes in cell shape and function and how such techniques can be used to control the phenotype and functions of immune cells such as macrophages and to develop novel anti-cancer and anti-rejection clinical therapies.

Indexed as

Actin CytoskeletonAnimalsBioengineeringCell ShapeGraft RejectionHumansMacrophagesMagnetic FieldsModels, TheoreticalNeoplasmsOrgan TransplantationPhenotyperhoA GTP-Binding ProteinSignal TransductionrhoA GTP-Binding ProteinActinCancerMacrophageMagnetic fieldRhoATransplantation

Identifiers

PMID30649660
OpenAlexW2910085190

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.