Evidence map›Paper›PMID 30649586›Full record

ArticleExperimental brain research2019

Low-intensity repetitive transcranial magnetic stimulation over prefrontal cortex in an animal model alters activity in the auditory thalamus but does not affect behavioural measures of tinnitus.

Wilhelmina H A M Mulders, K Leggett, V Mendis, H Tarawneh, J K Wong, J Rodger

Abstract read
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In one paragraph

Article in Experimental brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Animal Models of Tinnitus Treatment: Cochlear and Brain Stimulation.Current topics in behavioral neurosciences · 2021
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wilhelmina H A M MuldersSchool of Human Sciences, University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia. helmy.mulders@uwa.edu.au.ORCID http://orcid.org/0000-0001-8721-7357
K LeggettSchool of Human Sciences, University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia.
V MendisSchool of Human Sciences, University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia.
H TarawnehSchool of Human Sciences, University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia.
J K WongSchool of Human Sciences, University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia.
J RodgerSchool of Human Sciences, University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia.
The University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tinnitus, a phantom auditory percept, is strongly associated with cochlear trauma. The latter leads to central changes in auditory pathways such as increased spontaneous activity and this may be involved in tinnitus generation. As not all people with cochlear trauma develop tinnitus, recent studies argue that non-auditory structures, such as prefrontal cortex (PFC), play an important role in tinnitus development. As part of sensory gating circuitry, PFC may modify activity in auditory thalamus and consequently in auditory cortex. Human studies suggest that repetitive transcranial magnetic stimulation (rTMS), a non-invasive tool for neurostimulation, can alter tinnitus perception. This study used a guinea pig model of hearing loss and tinnitus to investigate effects of low-intensity rTMS (LI-rTMS) over PFC on tinnitus and spontaneous activity in auditory thalamus. In addition, immunohistochemistry for calbindin and parvalbumin in PFC was used to investigate the possible mechanism of action of LI-rTMS. Three treatment groups were compared: sham treatment, LI, low frequency (1 Hz) or LI, high frequency (10 Hz) rTMS (10 min/day, 2 weeks, weekdays only). None of the treatments affected the behavioural measures of tinnitus but spontaneous activity was significantly increased in auditory thalamus after 1 Hz and 10 Hz treatment. Immunostaining showed significant effects of rTMS on the density of calcium-binding protein expressing neurons in the dorsal regions of the PFC suggesting that rTMS treatment evoked plasticity in cortex. In addition, calbindin-positive neuron density in the superficial region of PFC was negatively correlated with spontaneous activity in auditory thalamus suggesting a possible mechanism for change in activity observed.

Indexed as

Action PotentialsAnimalsAudiometryBehavior, AnimalDisease Models, AnimalFemaleGeniculate BodiesGuinea PigsMalePrefrontal CortexPrepulse InhibitionTinnitusTranscranial Magnetic StimulationAudiogramCompound action potentialGap prepulse inhibitionGuinea pigTinnitus

Identifiers

PMID30649586
OpenAlexW2911189984

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.