ArticleJournal of experimental botany2019
A feedback loop between CaWRKY41 and H2O2 coordinates the response to Ralstonia solanacearum and excess cadmium in pepper.
Article in Journal of experimental botany, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 53 citations in OpenAlex.
- Transcription Factor TCP9 EnhancesPlants (Basel, Switzerland) · 2026Article
- Fine mapping and functional verification of the Cf-19 gene controlling leaf mold disease resistance in tomato.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- The Maize WRKY Transcription Factor ZmWRKY4 Confers Lead Tolerance by RegulatingPlants (Basel, Switzerland) · 2026Article
- The apple phosphate starvation response transcription factor MdPHR1 positively regulates zinc and cadmium tolerance.Plant cell reports · 2025Article
- Molecular Mechanisms of Cadmium Stress Resistance in Vegetable Crops.International journal of molecular sciences · 2025Review
- RsWRKY75 promotes ROS scavenging and cadmium efflux via activating the transcription of RsAPX1 and RsPDR8 in radish (Raphanus sativus L.).Plant cell reports · 2025Article
- WRKY Transcription Factors in Response to Metal Stress in Plants: A Review.International journal of molecular sciences · 2024Review
- The Uptake, Transfer, and Detoxification of Cadmium in Plants and Its Exogenous Effects.Cells · 2024Review
- Comparative Transcriptomics Analysis Reveals the Differences in Transcription between Resistant and Susceptible Pepper (Plants (Basel, Switzerland) · 2024Article
- The maize WRKY transcription factor ZmWRKY64 confers cadmium tolerance in Arabidopsis and maize (Zea mays L.).Plant cell reports · 2024Article
- Transcription factors involved in plant responses to cadmium-induced oxidative stress.Frontiers in plant science · 2024Review
- Response and Tolerance ofPlants (Basel, Switzerland) · 2023Article
- Physiological and molecular response and tolerance of Macleaya cordata to lead toxicity.BMC genomics · 2023Article
- CaWRKY50 Acts as a Negative Regulator in Response toPlants (Basel, Switzerland) · 2023Article
- SlWRKY30 and SlWRKY81 synergistically modulate tomato immunity toHorticulture research · 2023Article
- Characterization and Association of Rips Repertoire to Host Range of NovelMicroorganisms · 2023Article
- Ocimum sanctum, OscWRKY1, regulates phenylpropanoid pathway genes and promotes resistance to pathogen infection in Arabidopsis.Plant molecular biology · 2022Article
- WRKY genes provide novel insights into their role againstFrontiers in plant science · 2022Article
- Article
- Analysis of WRKY Resistance Gene Family inFrontiers in plant science · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
WRKY transcription factors have been implicated in both plant immunity and plant responses to cadmium (Cd); however, the mechanism underlying the crosstalk between these processes is unclear. Here, we characterized the roles of CaWRKY41, a group III WRKY transcription factor, in immunity against the pathogenic bacterium Ralstonia solanacearum and Cd stress responses in pepper (Capsicum annuum). CaWRKY41 was transcriptionally up-regulated in response to Cd exposure, R. solanacearum inoculation, and H2O2 treatment. Virus-induced silencing of CaWRKY41 increased Cd tolerance and R. solanacearum susceptibility, while heterologous overexpression of CaWRKY41 in Arabidopsis impaired Cd tolerance, and enhanced Cd and zinc (Zn) uptake and H2O2 accumulation. Genes encoding reactive oxygen species-scavenging enzymes were down-regulated in CaWRKY41-overexpressing Arabidopsis plants, whereas genes encoding Zn transporters and enzymes involved in H2O2 production were up-regulated. Consistent with these findings, the ocp3 (overexpressor of cationic peroxidase 3) mutant, which has elevated H2O2 levels, displayed enhanced sensitivity to Cd stress. These results suggest that a positive feedback loop between H2O2 accumulation and CaWRKY41 up-regulation coordinates the responses of pepper to R. solanacearum inoculation and Cd exposure. This mechanism might reduce Cd tolerance by increasing Cd uptake via Zn transporters, while enhancing resistance to R. solanacearum.
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