Evidence map›Paper›PMID 30649355›Full record

ArticleGlycobiology2019

Trypanosoma cruzi 13C-labeled O-Glycan standards for mass spectrometry.

M Osman Sheikh, Elisabet Gas-Pascual, John N Glushka, Juan M Bustamante, Lance Wells, Christopher M West

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glycobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

M Osman SheikhDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
Elisabet Gas-PascualDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
John N GlushkaComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
Juan M BustamanteCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, USA.
Lance WellsDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
Christopher M WestDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.
University of Georgia · US

Funding

TR&D1: Stem Cell and Induced Pluripotent Stem Cell Resources (Pages 116-134)P41GM103490 · NIGMS · UNIVERSITY OF GEORGIA · PI PIERCE, J. MICHAEL · 2012 to 2018
$13.7M
Recombinant Production of Glycosylation Enzymes for Biochem/Structural StudiesP01GM107012 · NIGMS · UNIVERSITY OF GEORGIA · PI MOREMEN, KELLEY · 2013 to 2017
$7.5M
Structure and Function in alpha-Dystroglycan GlycosylationR01GM111939 · NIGMS · UNIVERSITY OF GEORGIA · PI Lance Wells · 2014 to 2026
$4.0M
Glycoregulation of Skp1 in the cytoplasm and nucleusR01GM084383 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI BLADER, IRA J, WEST, CHRISTOPHER M. · 2009 to 2018
$2.9M
Enabling tools for protists pathogen glycobiologyR21AI123161 · NIAID · UNIVERSITY OF GEORGIA · PI TARLETON, RICK L, WELLS, LANCE · 2015 to 2016
$745k
NIGMS NIH HHS P01 GM107012NIGMS NIH HHS P41 GM103490NIGMS NIH HHS R01 GM084383NIGMS NIH HHS R01 GM111939
6 · The paper itself

Abstract

Trypanosoma cruzi is a protozoan parasite that causes Chagas disease, a debilitating condition that affects over 10 million humans in the American continents. In addition to its traditional mode of human entry via the "kissing bug" in endemic areas, the infection can also be spread in non-endemic countries through blood transfusion, organ transplantation, eating food contaminated with the parasites, and from mother to fetus. Previous NMR-based studies established that the parasite expresses a variety of strain-specific and developmentally-regulated O-glycans that may contribute to virulence. In this report, we describe five synthetic O-glycan analytical standards and show their potential to enable a more facile analysis of native O-glycan isomers based on mass spectrometry.

Indexed as

Carbohydrate ConformationCarbon IsotopesMass SpectrometryPolysaccharidesTrypanosoma cruziCarbon-13Carbon IsotopesPolysaccharidesmass spectrometryO-glycansParasitologyTrypanosoma cruzi

Identifiers

PMID30649355
PMCPMC6422234
OpenAlexW2909850176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.